biostudies-literatureJairath NKNational Psoriasis FoundationFoundation for the National Institutes of HealthDermatology Foundatione0277655https://www.ebi.ac.uk/biostudies/studies/S-EPMC9668185biostudies-literatureUnknown17(11)<h4>Background</h4>Large cell transformation (LCT) of Sezary Syndrome (SS) is a rare phenomenon. To date, there are no rigorous studies identifying risk factors for its development.<h4>Objectives</h4>Here, we seek to characterize the clinicopathologic risk factors that predispose patients with SS to develop LCT.<h4>Methods</h4>We retrospectively evaluated all SS patient records available in the Michigan Medicine Cancer Registry from 2010-2021. Clinical and pathologic variables were compared between groups. The Kaplan-Meier method and log-rank test were used to assess overall survival.<h4>Results</h4>Of 28 SS patients identified, eight patients experienced LCT, and 20 did not (NLCT). Peak lactate dehydrogenase (LDH) before LCT (p = 0.0012), maximum total body surface area (TBSA) involvementPloS onePredictors of large cell transformation in patients with Sezary Syndrome-A retrospective analysis.PMC9668185K01-AR072129Bardhi RTejasvi THristov ACRunge JSJairath RPatrick MJairath NKTsoi LCWang YWilcox RABledea RfalsePredictors of large cell transformation in patients with Sezary Syndrome-A retrospective analysis.<h4>Background</h4>Large cell transformation (LCT) of Sezary Syndrome (SS) is a rare phenomenon. To date, there are no rigorous studies identifying risk factors for its development.<h4>Objectives</h4>Here, we seek to characterize the clinicopathologic risk factors that predispose patients with SS to develop LCT.<h4>Methods</h4>We retrospectively evaluated all SS patient records available in the Michigan Medicine Cancer Registry from 2010-2021. Clinical and pathologic variables were compared between groups. The Kaplan-Meier method and log-rank test were used to assess overall survival.<h4>Results</h4>Of 28 SS patients identified, eight patients experienced LCT, and 20 did not (NLCT). Peak lactate dehydrogenase (LDH) before LCT (p = 0.0012), maximum total body surface area (TBSA) involvement2022-01-01T00:00:00Z20222025-06-01T01:36:09.434Z2025-06-01T01:36:09.434ZS-EPMC96681853638361810.1371/journal.pone.0277655