{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Zhang Y"],"pubmed_abstract":["Mitophagy and oxidative stress play important roles in Parkinson's disease (PD). Dysregulated mitophagy exacerbates mitochondrial oxidative damage; however, the regulatory mechanism of mitophagy is unclear. Here, we provide a potential mechanistic link between c-Abl, a nonreceptor tyrosine kinase, and mitophagy in PD progression. We found that c-Abl activation reduces the interaction of prohibitin 2 (PHB2) and microtubule-associated protein 1 light chain 3 (LC3) and decreases the expressive level of antioxidative stress proteins, including nuclear factor erythroid 2-related factor 2 (Nrf2), NADPH quinone oxidoreductase-1 (NQO-1), and the antioxidant enzyme heme oxygenase-1 (HO-1) in 1-methyl-4-phenylpyridinium- (MPP<sup>+</sup>-) lesioned SH-SY5Y cells. Importantly, we found that MPP<sup>+"],"journal":["Oxidative medicine and cellular longevity"],"pagination":["9233749"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9668474"],"repository":["biostudies-literature"],"pubmed_title":["Nonreceptor Tyrosine Kinase c-Abl-Mediated PHB2 Phosphorylation Aggravates Mitophagy Disorder in Parkinson's Disease Model."],"pmcid":["PMC9668474"],"pubmed_authors":["Shen M","Lai X","Wu J","Jin W","Yan J","Zhang Y","Yin S","Ma H","Sun D","Jiang M"],"additional_accession":[]},"is_claimable":false,"name":"Nonreceptor Tyrosine Kinase c-Abl-Mediated PHB2 Phosphorylation Aggravates Mitophagy Disorder in Parkinson's Disease Model.","description":"Mitophagy and oxidative stress play important roles in Parkinson's disease (PD). Dysregulated mitophagy exacerbates mitochondrial oxidative damage; however, the regulatory mechanism of mitophagy is unclear. Here, we provide a potential mechanistic link between c-Abl, a nonreceptor tyrosine kinase, and mitophagy in PD progression. We found that c-Abl activation reduces the interaction of prohibitin 2 (PHB2) and microtubule-associated protein 1 light chain 3 (LC3) and decreases the expressive level of antioxidative stress proteins, including nuclear factor erythroid 2-related factor 2 (Nrf2), NADPH quinone oxidoreductase-1 (NQO-1), and the antioxidant enzyme heme oxygenase-1 (HO-1) in 1-methyl-4-phenylpyridinium- (MPP<sup>+</sup>-) lesioned SH-SY5Y cells. Importantly, we found that MPP<sup>+","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T14:23:01.626Z","creation":"2025-04-21T14:23:01.626Z"},"accession":"S-EPMC9668474","cross_references":{"pubmed":["36406767"],"doi":["10.1155/2022/9233749"]}}