biostudies-literatureUnknown36Khedher LSeveral postmortem studies have shown iron accumulation in the substantia nigra of Parkinson's disease patients. Iron concentration can be estimated via MRI-R₂^∗ mapping. To assess the changes in R₂^∗ occurring in Parkinson's disease patients compared to controls, a multicentre transversal study was carried out on a large cohort of Parkinson's disease patients (n = 163) with matched controls (n = 82). In this study, 44 patients and 11 controls were removed due to motion artefacts, 21 patient and 6 controls to preserve matching. Thus, 98 patients and 65 age and sex-matched healthy subjects were selected with enough image quality. The study was conducted on patients with early to late stage Parkinson's disease. The images were acquired at 3Tesla in 1NeuroImage. Clinical103231https://www.ebi.ac.uk/biostudies/studies/S-EPMC9668635biostudies-literatureIntrasubject subcortical quantitative referencing to boost MRI sensitivity to Parkinson's disease.PMC9668635Menjot de Champfleur NRemy PChassain CGeny CDoe de Maindreville AChupin MKhedher LPortefaix CThobois SMetereau EMarques AMoro EVidailhet MSpampinato UPeran PCarriere NFraix VDurand ER study groupDurif FVidal TPereira BFenelon GMangone GRascol OBonny JMDefebvre LLehericy SLuc Houeto JFrismand SSchmitt ECorvol JCMeissner WColin OfalseIntrasubject subcortical quantitative referencing to boost MRI sensitivity to Parkinson's disease.Several postmortem studies have shown iron accumulation in the substantia nigra of Parkinson's disease patients. Iron concentration can be estimated via MRI-R₂^∗ mapping. To assess the changes in R₂^∗ occurring in Parkinson's disease patients compared to controls, a multicentre transversal study was carried out on a large cohort of Parkinson's disease patients (n = 163) with matched controls (n = 82). In this study, 44 patients and 11 controls were removed due to motion artefacts, 21 patient and 6 controls to preserve matching. Thus, 98 patients and 65 age and sex-matched healthy subjects were selected with enough image quality. The study was conducted on patients with early to late stage Parkinson's disease. The images were acquired at 3Tesla in 12022-01-01T00:00:00Z20222026-05-10T06:16:54.169Z2024-11-07T05:02:04.205ZS-EPMC96686353627975310.1016/j.nicl.2022.103231