biostudies-literatureUnknown9Gao YThis study aimed to investigate the effects of dietary squalene (SQ) supplementation on the growth performance of early-weaned piglets. Twenty early-weaned piglets were randomly divided into two groups, the squalene group (SQ) and the control group (CON). The CON group was fed a basal diet, and the SQ group was fed a basal diet with 250 mg/kg squalene. The feeding period lasted 21 days. The results showed that SQ significantly increased the final body weight (FWB, <i>P</i> < 0.05), average daily gain (ADG, <i>P</i> < 0.05), and average daily feed intake (ADFI, <i>P</i> < 0.05) and significantly decreased the F/G ratio (feed intake/gain, <i>P</i> < 0.05) and diarrhea index (DI, <i>P</i> < 0.05). In terms of blood biochemical indicators, SQ significantly increased anti-inflammatory factors sFrontiers in veterinary science995548https://www.ebi.ac.uk/biostudies/studies/S-EPMC9669083biostudies-literatureDietary supplementation of squalene increases the growth performance of early-weaned piglets by improving gut microbiota, intestinal barrier, and blood antioxidant capacity.PMC9669083Li YXiang DGao YMa XZhou YfalseDietary supplementation of squalene increases the growth performance of early-weaned piglets by improving gut microbiota, intestinal barrier, and blood antioxidant capacity.This study aimed to investigate the effects of dietary squalene (SQ) supplementation on the growth performance of early-weaned piglets. Twenty early-weaned piglets were randomly divided into two groups, the squalene group (SQ) and the control group (CON). The CON group was fed a basal diet, and the SQ group was fed a basal diet with 250 mg/kg squalene. The feeding period lasted 21 days. The results showed that SQ significantly increased the final body weight (FWB, <i>P</i> < 0.05), average daily gain (ADG, <i>P</i> < 0.05), and average daily feed intake (ADFI, <i>P</i> < 0.05) and significantly decreased the F/G ratio (feed intake/gain, <i>P</i> < 0.05) and diarrhea index (DI, <i>P</i> < 0.05). In terms of blood biochemical indicators, SQ significantly increased anti-inflammatory factors s2022-01-01T00:00:00Z20222025-04-19T10:37:31.661Z2025-04-19T10:37:31.661ZS-EPMC96690833640608010.3389/fvets.2022.995548