{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Barletta JA"],"funding":["NCI NIH HHS"],"pagination":["1706-1715"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9669222"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(12)"],"pubmed_abstract":["NUT carcinoma (NC) is a rare subtype of squamous cell carcinoma defined by NUTM1 rearrangements encoding NUT fusion oncoproteins (the most frequent fusion partner being BRD4 ) that carries a very poor prognosis, with most patients dying in under 1 year. Only rare primary thyroid NCs have been reported. Here, we evaluated a series of 14 cases. The median patient age at diagnosis was 38 years (range: 17 to 72 y). Eight of 13 cases with slides available for review (62%) showed a morphology typical of NC, whereas 5 (38%) had a non-NC-like morphology, some of which had areas of cribriform or fused follicular architecture resembling a follicular cell-derived thyroid carcinoma. For cases with immunohistochemistry results, 85% (11/13) were positive for NUT on biopsy or resection, though staining w"],"journal":["The American journal of surgical pathology"],"pubmed_title":["NUTM1 -rearranged Carcinoma of the Thyroid : A Distinct Subset of NUT Carcinoma Characterized by Frequent NSD3 - NUTM1 Fusions."],"pmcid":["PMC9669222"],"funding_grant_id":["R01 CA124633","P30 CA008748"],"pubmed_authors":["Bocklage T","Weissferdt A","Ghossein RA","Ng TL","Bell D","Chau NG","Limaye S","Zhang S","French CA","Lopez CA","Hertzler HJ","Boisselier P","Gilday SD","Xu B","Barletta JA","Cipriani NA","Afkhami M","Costes-Martineau V","Kramer AM"],"additional_accession":[]},"is_claimable":false,"name":"NUTM1 -rearranged Carcinoma of the Thyroid : A Distinct Subset of NUT Carcinoma Characterized by Frequent NSD3 - NUTM1 Fusions.","description":"NUT carcinoma (NC) is a rare subtype of squamous cell carcinoma defined by NUTM1 rearrangements encoding NUT fusion oncoproteins (the most frequent fusion partner being BRD4 ) that carries a very poor prognosis, with most patients dying in under 1 year. Only rare primary thyroid NCs have been reported. Here, we evaluated a series of 14 cases. The median patient age at diagnosis was 38 years (range: 17 to 72 y). Eight of 13 cases with slides available for review (62%) showed a morphology typical of NC, whereas 5 (38%) had a non-NC-like morphology, some of which had areas of cribriform or fused follicular architecture resembling a follicular cell-derived thyroid carcinoma. For cases with immunohistochemistry results, 85% (11/13) were positive for NUT on biopsy or resection, though staining w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T09:50:15.936Z","creation":"2025-02-19T01:17:36.195Z"},"accession":"S-EPMC9669222","cross_references":{"pubmed":["36040068"],"doi":["10.1097/pas.0000000000001967","10.1097/PAS.0000000000001967"]}}