{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hegazy A"],"funding":["Deutsche Forschungsgemeinschaft","Deutsches Zentrum f?r Infektionsforschung","National Research Centre"],"pagination":["41212-41223"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9670689"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(45)"],"pubmed_abstract":["The evolution of drug-resistant viral strains following natural acquisition of resistance mutations is a major obstacle to antiviral therapy. Besides the improper prescription of the currently licensed anti-influenza medications, M2-blockers and neuraminidase inhibitors, to control poultry outbreaks/infections potentiates the emergence of drug-resistant influenza variants. Therefore, there is always a necessity to find out new alternatives with potent activity and high safety. Plant extracts and plant-based chemicals represent a historical antiviral resource with remarkable safety <i>in vitro</i> and <i>in vivo</i> to control the emerging and remerging health threats caused by viral infections. Herein, a panel of purified plant extracts and subsequent plant-derived chemicals were evaluated"],"journal":["ACS omega"],"pubmed_title":["Robust Antiviral Activity of Santonica Flower Extract (<i>Artemisia cina</i>) against Avian and Human Influenza A Viruses: <i>In Vitro</i> and Chemoinformatic Studies."],"pmcid":["PMC9670689"],"funding_grant_id":["12010126","TT110801","SFB-TR 84"],"pubmed_authors":["Mraheil MA","Shehata M","Mostafa A","Hegazy A","Yahya G","El-Shazly AM","Nasr NF","El-Halawany AM","Abo Shama NM","Ali MA","Mostafa I","Elshaier YAMM","Mahmoud SH"],"additional_accession":[]},"is_claimable":false,"name":"Robust Antiviral Activity of Santonica Flower Extract (<i>Artemisia cina</i>) against Avian and Human Influenza A Viruses: <i>In Vitro</i> and Chemoinformatic Studies.","description":"The evolution of drug-resistant viral strains following natural acquisition of resistance mutations is a major obstacle to antiviral therapy. Besides the improper prescription of the currently licensed anti-influenza medications, M2-blockers and neuraminidase inhibitors, to control poultry outbreaks/infections potentiates the emergence of drug-resistant influenza variants. Therefore, there is always a necessity to find out new alternatives with potent activity and high safety. Plant extracts and plant-based chemicals represent a historical antiviral resource with remarkable safety <i>in vitro</i> and <i>in vivo</i> to control the emerging and remerging health threats caused by viral infections. Herein, a panel of purified plant extracts and subsequent plant-derived chemicals were evaluated","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-05-31T23:32:31.612Z","creation":"2025-05-31T23:32:31.612Z"},"accession":"S-EPMC9670689","cross_references":{"pubmed":["36406485"],"doi":["10.1021/acsomega.2c04867"]}}