biostudies-literatureHegazy ADeutsche ForschungsgemeinschaftDeutsches Zentrum f?r InfektionsforschungNational Research Centre41212-41223https://www.ebi.ac.uk/biostudies/studies/S-EPMC9670689biostudies-literatureUnknown7(45)The evolution of drug-resistant viral strains following natural acquisition of resistance mutations is a major obstacle to antiviral therapy. Besides the improper prescription of the currently licensed anti-influenza medications, M2-blockers and neuraminidase inhibitors, to control poultry outbreaks/infections potentiates the emergence of drug-resistant influenza variants. Therefore, there is always a necessity to find out new alternatives with potent activity and high safety. Plant extracts and plant-based chemicals represent a historical antiviral resource with remarkable safety <i>in vitro</i> and <i>in vivo</i> to control the emerging and remerging health threats caused by viral infections. Herein, a panel of purified plant extracts and subsequent plant-derived chemicals were evaluatedACS omegaRobust Antiviral Activity of Santonica Flower Extract (<i>Artemisia cina</i>) against Avian and Human Influenza A Viruses: <i>In Vitro</i> and Chemoinformatic Studies.PMC967068912010126TT110801SFB-TR 84Mraheil MAShehata MMostafa AHegazy AYahya GEl-Shazly AMNasr NFEl-Halawany AMAbo Shama NMAli MAMostafa IElshaier YAMMMahmoud SHfalseRobust Antiviral Activity of Santonica Flower Extract (<i>Artemisia cina</i>) against Avian and Human Influenza A Viruses: <i>In Vitro</i> and Chemoinformatic Studies.The evolution of drug-resistant viral strains following natural acquisition of resistance mutations is a major obstacle to antiviral therapy. Besides the improper prescription of the currently licensed anti-influenza medications, M2-blockers and neuraminidase inhibitors, to control poultry outbreaks/infections potentiates the emergence of drug-resistant influenza variants. Therefore, there is always a necessity to find out new alternatives with potent activity and high safety. Plant extracts and plant-based chemicals represent a historical antiviral resource with remarkable safety <i>in vitro</i> and <i>in vivo</i> to control the emerging and remerging health threats caused by viral infections. Herein, a panel of purified plant extracts and subsequent plant-derived chemicals were evaluated2022-01-01T00:00:00Z2022 Nov2025-05-31T23:32:31.612Z2025-05-31T23:32:31.612ZS-EPMC96706893640648510.1021/acsomega.2c04867