{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alhaj-Suliman SO"],"funding":["NIEHS NIH HHS","National Institutes of Health"],"pagination":["390-399"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9670863"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(5)"],"pubmed_abstract":["Background
Despite recent therapeutic advances, osteoarthritis continues to be a challenging health problem, especially in the elderly population. Opioids, which are potent analgesics, have shown an extraordinary ability to reduce intense pain in many osteoarthritic clinical trials; however, there is an increased need for a study to integrate the reported outcomes and utilize them to achieve a better understanding. Herein, efficacy and safety aspects of opioids used to manage osteoarthritic pain were assessed and compared using a model-based meta-analysis (MBMA).Methods
To perform the analysis, a comprehensive database consisting of pain relief compounds with information on summary-level of efficacy over time, adverse events and dropout rates was compiled from multiple sour"],"journal":["Current drug metabolism"],"pubmed_title":["Model-based Meta-analysis to Compare Primary Efficacy-endpoint, Efficacy-time Course, Safety, and Tolerability of Opioids Used in the Management of Osteoarthritic Pain in Humans."],"pmcid":["PMC9670863"],"funding_grant_id":["P30 ES005605","P30 CA086862"],"pubmed_authors":["Alhaj-Suliman SO","Milavetz G","Salem AK"],"additional_accession":[]},"is_claimable":false,"name":"Model-based Meta-analysis to Compare Primary Efficacy-endpoint, Efficacy-time Course, Safety, and Tolerability of Opioids Used in the Management of Osteoarthritic Pain in Humans.","description":"Background
Despite recent therapeutic advances, osteoarthritis continues to be a challenging health problem, especially in the elderly population. Opioids, which are potent analgesics, have shown an extraordinary ability to reduce intense pain in many osteoarthritic clinical trials; however, there is an increased need for a study to integrate the reported outcomes and utilize them to achieve a better understanding. Herein, efficacy and safety aspects of opioids used to manage osteoarthritic pain were assessed and compared using a model-based meta-analysis (MBMA).Methods
To perform the analysis, a comprehensive database consisting of pain relief compounds with information on summary-level of efficacy over time, adverse events and dropout rates was compiled from multiple sour","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-21T14:17:20.088Z","creation":"2025-04-21T14:17:20.088Z"},"accession":"S-EPMC9670863","cross_references":{"pubmed":["32407270"],"doi":["10.2174/1389200221666200514130441"]}}