{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(11)"],"submitter":["Ma Y"],"pubmed_abstract":["<h4>Introduction</h4>When patients receive patient-controlled intravenous analgesia (PCIA), no basal infusion is always recommended, as the addition of a basal infusion increases the occurrence of postoperative opioid-induced respiratory depression. However, few studies have investigated whether low basal infusions increase the incidence of postoperative hypoxaemia relative to no basal infusion. We intend to conduct a clinical trial to test the hypothesis that PCIA with a low basal infusion does not increase the occurrence of postoperative hypoxaemia relative to PCIA with no basal infusion.<h4>Methods and analysis</h4>This single-centre parallel randomised controlled clinical trial will be conducted with 160 patients undergoing gastrointestinal tumour surgery. The assigned nurse will set a"],"journal":["BMJ open"],"pagination":["e064581"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9670915"],"repository":["biostudies-literature"],"pubmed_title":["Effects of hydromorphone-based intravenous patient-controlled analgesia with and without a low basal infusion on postoperative hypoxaemia: study protocol for a randomised controlled clinical trial."],"pmcid":["PMC9670915"],"pubmed_authors":["Yang X","Mu X","Luo J","Feng X","Deng Z","Ma Y","Lin J","Meng Y","Nie H"],"additional_accession":[]},"is_claimable":false,"name":"Effects of hydromorphone-based intravenous patient-controlled analgesia with and without a low basal infusion on postoperative hypoxaemia: study protocol for a randomised controlled clinical trial.","description":"<h4>Introduction</h4>When patients receive patient-controlled intravenous analgesia (PCIA), no basal infusion is always recommended, as the addition of a basal infusion increases the occurrence of postoperative opioid-induced respiratory depression. However, few studies have investigated whether low basal infusions increase the incidence of postoperative hypoxaemia relative to no basal infusion. We intend to conduct a clinical trial to test the hypothesis that PCIA with a low basal infusion does not increase the occurrence of postoperative hypoxaemia relative to PCIA with no basal infusion.<h4>Methods and analysis</h4>This single-centre parallel randomised controlled clinical trial will be conducted with 160 patients undergoing gastrointestinal tumour surgery. The assigned nurse will set a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-21T14:19:02.868Z","creation":"2025-04-21T14:19:02.868Z"},"accession":"S-EPMC9670915","cross_references":{"pubmed":["36385038"],"doi":["10.1136/bmjopen-2022-064581"]}}