{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bertrand BP"],"funding":["NIAID NIH HHS","NCI NIH HHS","NIGMS NIH HHS"],"pagination":["e0042822"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9670962"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["90(11)"],"pubmed_abstract":["Biofilms are bacterial communities characterized by antibiotic tolerance. Staphylococcus aureus is a leading cause of biofilm infections on medical devices, including prosthetic joints, which represent a significant health care burden. The major leukocyte infiltrate associated with S. aureus prosthetic joint infection (PJI) is granulocytic myeloid-derived suppressor cells (G-MDSCs), which produce IL-10 to promote biofilm persistence by inhibiting monocyte and macrophage proinflammatory activity. To determine how S. aureus biofilm responds to G-MDSCs and macrophages, biofilms were cocultured with either leukocyte population followed by RNA sequencing. Several genes involved in fermentative pathways were significantly upregulated in S. aureus biofilm following G-MDSC coculture, including for"],"journal":["Infection and immunity"],"pubmed_title":["Role of Staphylococcus aureus Formate Metabolism during Prosthetic Joint Infection."],"pmcid":["PMC9670962"],"funding_grant_id":["P30 CA036727","P30 GM110768","P20 GM103427","P01 AI083211","R01 AI125588"],"pubmed_authors":["West SC","Ali H","Heim CE","Thomas VC","Kielian T","Bertrand BP","Chaudhari SS"],"additional_accession":[]},"is_claimable":false,"name":"Role of Staphylococcus aureus Formate Metabolism during Prosthetic Joint Infection.","description":"Biofilms are bacterial communities characterized by antibiotic tolerance. Staphylococcus aureus is a leading cause of biofilm infections on medical devices, including prosthetic joints, which represent a significant health care burden. The major leukocyte infiltrate associated with S. aureus prosthetic joint infection (PJI) is granulocytic myeloid-derived suppressor cells (G-MDSCs), which produce IL-10 to promote biofilm persistence by inhibiting monocyte and macrophage proinflammatory activity. To determine how S. aureus biofilm responds to G-MDSCs and macrophages, biofilms were cocultured with either leukocyte population followed by RNA sequencing. Several genes involved in fermentative pathways were significantly upregulated in S. aureus biofilm following G-MDSC coculture, including for","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-06-13T06:16:14.778Z","creation":"2025-04-06T14:10:09.067Z"},"accession":"S-EPMC9670962","cross_references":{"pubmed":["36286525"],"doi":["10.1128/iai.00428-22"]}}