biostudies-literatureUnknown23(12)Zuin M<h4>Background</h4>Acute pulmonary embolism has been recognized as a frequent complication of COVID-19 infection influencing the clinical course and outcomes of these patients.<h4>Objectives</h4>We performed a systematic review and meta-analysis to evaluate the mortality risk in COVID-19 Italian patients complicated by acute pulmonary embolism in the short-term period.<h4>Methods</h4>The study was performed in accordance with the Preferred Report Items for Systematic Reviews and Meta-analyses guidelines. PubMed-MEDLINE and Scopus databases were systematically searched for articles, published in the English language and enrolling Italian cohorts with confirmed COVID-19 infection from inception through 20 October 2021. Mortality risk data were pooled using the Mantel-Haenszel random effects Journal of cardiovascular medicine (Hagerstown, Md.)773-778https://www.ebi.ac.uk/biostudies/studies/S-EPMC9671546biostudies-literatureCOVID-19 patients with acute pulmonary embolism have a higher mortality risk: systematic review and meta-analysis based on Italian cohorts.PMC9671546Rigatelli GQuadretti LZuin MZuliani GRoncon LBilato CfalseCOVID-19 patients with acute pulmonary embolism have a higher mortality risk: systematic review and meta-analysis based on Italian cohorts.<h4>Background</h4>Acute pulmonary embolism has been recognized as a frequent complication of COVID-19 infection influencing the clinical course and outcomes of these patients.<h4>Objectives</h4>We performed a systematic review and meta-analysis to evaluate the mortality risk in COVID-19 Italian patients complicated by acute pulmonary embolism in the short-term period.<h4>Methods</h4>The study was performed in accordance with the Preferred Report Items for Systematic Reviews and Meta-analyses guidelines. PubMed-MEDLINE and Scopus databases were systematically searched for articles, published in the English language and enrolling Italian cohorts with confirmed COVID-19 infection from inception through 20 October 2021. Mortality risk data were pooled using the Mantel-Haenszel random effects 2022-01-01T00:00:00Z2022 Dec2025-04-05T11:36:35.519Z2025-02-19T00:47:17.415ZS-EPMC96715463616632610.2459/JCM.0000000000001354