{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Chen Z"],"funding":["Natural Science Foundation of Heilongjiang Province"],"pubmed_abstract":["The present study aimed to search for functional mutations within the promoter of porcine <i>STAT3</i> and to provide causative genetic variants associated with piglet diarrhea. We firstly confirmed that <i>STAT3</i> expressed higher in the small intestine than in the spleen, stomach and large intestine of SPF piglets, respectively (<i>P</i> < 0.05). Then, 10 genetic variations in the porcine STAT3 promoter region was identified by direct sequencing. Among them, three mutations SNP1: g.-870 G>A, SNP2: g.-584 A>C and a 6-bp Indel in the promoter region that displayed significant differential transcriptional activities were identified. Association analyses showed that SNP1: g.-870 G>A was significantly associated with piglet diarrhea (<i>P</i> < 0.05) and the GG animals had lower diarrhea sc"],"journal":["Frontiers in veterinary science"],"pagination":["1034187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9672087"],"repository":["biostudies-literature"],"pubmed_title":["A functional mutation associated with piglet diarrhea partially by regulating the transcription of porcine <i>STAT3</i>."],"pmcid":["PMC9672087"],"pubmed_authors":["Yang X","Niu B","Liu L","Chen Z","Yao D","Di S","Cai J","Guo D","Kou M","Wang X","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"A functional mutation associated with piglet diarrhea partially by regulating the transcription of porcine <i>STAT3</i>.","description":"The present study aimed to search for functional mutations within the promoter of porcine <i>STAT3</i> and to provide causative genetic variants associated with piglet diarrhea. We firstly confirmed that <i>STAT3</i> expressed higher in the small intestine than in the spleen, stomach and large intestine of SPF piglets, respectively (<i>P</i> < 0.05). Then, 10 genetic variations in the porcine STAT3 promoter region was identified by direct sequencing. Among them, three mutations SNP1: g.-870 G>A, SNP2: g.-584 A>C and a 6-bp Indel in the promoter region that displayed significant differential transcriptional activities were identified. Association analyses showed that SNP1: g.-870 G>A was significantly associated with piglet diarrhea (<i>P</i> < 0.05) and the GG animals had lower diarrhea sc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T22:32:04.508Z","creation":"2025-04-06T17:16:04.06Z"},"accession":"S-EPMC9672087","cross_references":{"pubmed":["36406089"],"doi":["10.3389/fvets.2022.1034187"]}}