biostudies-literatureUnknown38Schneider S<h4>Background and purpose</h4>Motion mitigation is of crucial importance in particle therapy (PT) of patients with abdominal tumors to ensure high-precision irradiation. Magnetic resonance imaging (MRI) is an excellent modality for target volume delineation and motion estimation of mobile soft-tissue tumors. Thus, the aims of this study were to develop an MRI- and PT-compatible abdominal compression device, to investigate its effect on pancreas motion reduction, and to evaluate patient tolerability and acceptance.<h4>Materials and methods</h4>In a prospective clinical study, 16 patients with abdominal tumors received an individualized polyethylene-based abdominal corset. Pancreas motion was analyzed using time- and phase resolved MRI scans (orthogonal 2D-cine and 4D MRI) with and without Clinical and translational radiation oncology111-116https://www.ebi.ac.uk/biostudies/studies/S-EPMC9672128biostudies-literatureReduction of intrafraction pancreas motion using an abdominal corset compatible with proton therapy and MRI.PMC9672128Lohaus FSchneider SHoffmann ALValentini CHaak DThiele JJentsch CPlatzek IG C Troost EStefanowicz SfalseReduction of intrafraction pancreas motion using an abdominal corset compatible with proton therapy and MRI.<h4>Background and purpose</h4>Motion mitigation is of crucial importance in particle therapy (PT) of patients with abdominal tumors to ensure high-precision irradiation. Magnetic resonance imaging (MRI) is an excellent modality for target volume delineation and motion estimation of mobile soft-tissue tumors. Thus, the aims of this study were to develop an MRI- and PT-compatible abdominal compression device, to investigate its effect on pancreas motion reduction, and to evaluate patient tolerability and acceptance.<h4>Materials and methods</h4>In a prospective clinical study, 16 patients with abdominal tumors received an individualized polyethylene-based abdominal corset. Pancreas motion was analyzed using time- and phase resolved MRI scans (orthogonal 2D-cine and 4D MRI) with and without 2023-01-01T00:00:00Z2023 Jan2025-04-19T16:13:03.09Z2025-04-19T16:13:03.09ZS-EPMC96721283640748810.1016/j.ctro.2022.11.006