biostudies-literaturePalmioli AMinistero dell&apos;Universit? e della RicercaItalian Institute for Planetary Health3152-3167https://www.ebi.ac.uk/biostudies/studies/S-EPMC9673154biostudies-literatureUnknown13(22)The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies. The search for natural compounds, whose intake through diet can help prevent the main biochemical mechanisms responsible for AD onset, led us to screen hops, one of the main ingredients of beer. To explore the chemical variability of hops, we characterized four hop varieties, <i>i.e.</i>, Cascade, Saaz, Tettnang, and Summit. We investigated the potential multitarget hop activity, in particular its ability to hinder Aβ1-42 peptide aggregation and cytotoxicity, its antioxidant properties, and its ability to enhance autophagy, promoting the clearance of misfolded and aggregateACS chemical neuroscienceAlzheimer's Disease Prevention through Natural Compounds: Cell-Free<i>, In Vitro</i>, and <i>In Vivo</i> Dissection of Hop (<i>Humulus lupulus</i> L.) Multitarget Activity.PMC9673154Dipartimenti di Eccellenza 2017(FFABR)-MIUR 2017Sala GFerrarese CAiroldi CDe Luigi ABruzzone CZoia CPBazzini CInserra MDe Noni IMazzoni VSalmona MColombo LDiomede LPalmioli AfalseAlzheimer's Disease Prevention through Natural Compounds: Cell-Free<i>, In Vitro</i>, and <i>In Vivo</i> Dissection of Hop (<i>Humulus lupulus</i> L.) Multitarget Activity.The relevant social and economic costs associated with aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), entail considerable efforts to develop effective preventive and therapeutic strategies. The search for natural compounds, whose intake through diet can help prevent the main biochemical mechanisms responsible for AD onset, led us to screen hops, one of the main ingredients of beer. To explore the chemical variability of hops, we characterized four hop varieties, <i>i.e.</i>, Cascade, Saaz, Tettnang, and Summit. We investigated the potential multitarget hop activity, in particular its ability to hinder Aβ1-42 peptide aggregation and cytotoxicity, its antioxidant properties, and its ability to enhance autophagy, promoting the clearance of misfolded and aggregate2022-01-01T00:00:00Z2022 Nov2025-06-01T02:48:42.259Z2025-06-01T02:48:42.259ZS-EPMC96731543628303510.1021/acschemneuro.2c00444