{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murphy KR"],"funding":["HHS | NIH | National Institute of Mental Health","NIDA NIH HHS","NHLBI NIH HHS","NIMH NIH HHS","HHS | NIH | National Institute on Drug Abuse","HHS | NIH | National Heart, Lung, and Blood Institute","NINDS NIH HHS"],"pagination":["e2206828119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9674244"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(46)"],"pubmed_abstract":["Focused ultrasound (FUS) is a powerful tool for noninvasive modulation of deep brain activity with promising therapeutic potential for refractory epilepsy; however, tools for examining FUS effects on specific cell types within the deep brain do not yet exist. Consequently, how cell types within heterogeneous networks can be modulated and whether parameters can be identified to bias these networks in the context of complex behaviors remains unknown. To address this, we developed a fiber Photometry Coupled focused Ultrasound System (PhoCUS) for simultaneously monitoring FUS effects on neural activity of subcortical genetically targeted cell types in freely behaving animals. We identified a parameter set that selectively increases activity of parvalbumin interneurons while suppressing excitatory neurons in the hippocampus. A net inhibitory effect localized to the hippocampus was further confirmed through whole brain metabolic imaging. Finally, these inhibitory selective parameters achieved significant spike suppression in the kainate model of chronic temporal lobe epilepsy, opening the door for future noninvasive therapies."],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["A tool for monitoring cell type-specific focused ultrasound neuromodulation and control of chronic epilepsy."],"pmcid":["PMC9674244"],"funding_grant_id":["R21 DA055056","R01 NS121106","T32 HL110952","MH116470","R01 MH116470","R01 HL150566","5T32HL110952-08","F32 HL149458","R00 NS126725","1F32HL149458-01A1","DA055056"],"pubmed_authors":["Firouzi K","Murphy KR","Gomez JL","Good CH","Leung SA","Michaelides M","Li N","Khuri-Yakub BPT","Qiu Z","Farrell JS","de Lecea L","Soltesz I","Butts Pauly K","Stedman QG"],"additional_accession":[]},"is_claimable":false,"name":"A tool for monitoring cell type-specific focused ultrasound neuromodulation and control of chronic epilepsy.","description":"Focused ultrasound (FUS) is a powerful tool for noninvasive modulation of deep brain activity with promising therapeutic potential for refractory epilepsy; however, tools for examining FUS effects on specific cell types within the deep brain do not yet exist. Consequently, how cell types within heterogeneous networks can be modulated and whether parameters can be identified to bias these networks in the context of complex behaviors remains unknown. To address this, we developed a fiber Photometry Coupled focused Ultrasound System (PhoCUS) for simultaneously monitoring FUS effects on neural activity of subcortical genetically targeted cell types in freely behaving animals. We identified a parameter set that selectively increases activity of parvalbumin interneurons while suppressing excitatory neurons in the hippocampus. A net inhibitory effect localized to the hippocampus was further confirmed through whole brain metabolic imaging. Finally, these inhibitory selective parameters achieved significant spike suppression in the kainate model of chronic temporal lobe epilepsy, opening the door for future noninvasive therapies.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-06-04T05:49:44.713Z","creation":"2025-04-19T13:31:09.563Z"},"accession":"S-EPMC9674244","cross_references":{"pubmed":["36343238"],"doi":["10.1073/pnas.2206828119"]}}