biostudies-literatureUnknown109(11)Tudini ESharing genomic variant interpretations across laboratories promotes consistency in variant assertions. A landscape analysis of Australian clinical genetic-testing laboratories in 2017 identified that, despite the national-accreditation-body recommendations encouraging laboratories to submit genotypic data to clinical databases, fewer than 300 variants had been shared to the ClinVar public database. Consultations with Australian laboratories identified resource constraints limiting routine application of manual processes, consent issues, and differences in interpretation systems as barriers to sharing. This information was used to define key needs and solutions required to enable national sharing of variant interpretations. The Shariant platform, using both the GRCh37 and GRCh38 genome buiAmerican journal of human genetics1960-1973https://www.ebi.ac.uk/biostudies/studies/S-EPMC9674965biostudies-literatureShariant platform: Enabling evidence sharing across Australian clinical genetic-testing laboratories to support variant interpretation.PMC9674965Scott HSBurnett JRWoods RDouglas ESanchez LPhelan DSadedin SStark ZBurrows LBaxter LSimsek ASchreiber AWBrion KHackett EChristodoulou JMehrtens RQuinn MCJZiolkowski ABrion MJShariant ConsortiumChong BChan EChristie MHadler JHa TLunke SGallagher RLThorne NPLawrence DMBoughtwood TFByrne AWells AVU JVakulin CGHenry DBell DANones KLuxford CDubowsky AAndrews JMeldrum CDoig KDBuckley MBlack MBeshay VFriend KKrishnaraj RVanwageningen OClifton-Bligh RSpurdle ABDinger MEBaker NCox KPearson JVAllcock RPontikinas EBrown ADooley SCliffe CEllul MHipwell MAshton KSoubrier JMossman DFisk KRoscioli TDejong LRawlings LHSigalas EHolman KMcManus SBennetts BHooper AJLundie BLe HKang SNguyen LTHo GKassahn KSBeilby JTudini EGao SSan Leong HHollway GFanjul Fernandez MFellowes APantaleo SJHolds DCheong PLScott RWise CAFarnsworth EAkesson LJackson MDavis MRMarty ARavine AKing-Smith SLSimons KThompson BAMcPhillips MFortuno CLau CPalmer KfalseShariant platform: Enabling evidence sharing across Australian clinical genetic-testing laboratories to support variant interpretation.Sharing genomic variant interpretations across laboratories promotes consistency in variant assertions. A landscape analysis of Australian clinical genetic-testing laboratories in 2017 identified that, despite the national-accreditation-body recommendations encouraging laboratories to submit genotypic data to clinical databases, fewer than 300 variants had been shared to the ClinVar public database. Consultations with Australian laboratories identified resource constraints limiting routine application of manual processes, consent issues, and differences in interpretation systems as barriers to sharing. This information was used to define key needs and solutions required to enable national sharing of variant interpretations. The Shariant platform, using both the GRCh37 and GRCh38 genome bui2022-01-01T00:00:00Z2022 Nov2025-04-22T18:33:22.949Z2025-04-06T02:28:30.203ZS-EPMC96749653633261110.1016/j.ajhg.2022.10.006