{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song J"],"funding":["National Natural Science Foundation of China"],"pagination":["7096"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9675819"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["RIG-I/DDX58 plays a key role in host innate immunity. However, its therapeutic potential for inflammation-related cancers remains to be explored. Here we identify frameshift germline mutations of RIG-I occurring in patients with colon cancer. Accordingly, Rig-i<sup>fs/fs</sup> mice bearing a frameshift mutant Rig-i exhibit increased susceptibility to colitis-related colon cancer as well as enhanced inflammatory response to chemical, virus or bacteria. In addition to interruption of Rig-i mRNA translation, the Rig-i mutation changes the secondary structure of Rig-i pre-mRNA and impairs its association with DHX9, consequently inducing a circular RNA generation from Rig-i transcript, thereby, designated as circRIG-I. CircRIG-I is frequently upregulated in colon cancers and its upregulation pr"],"journal":["Nature communications"],"pubmed_title":["Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling."],"pmcid":["PMC9675819"],"funding_grant_id":["81991505","82022032","82221003"],"pubmed_authors":["Yin Y","Ma L","Tian W","Zhang X","Cao Y","Zhao W","Lu D","Song J","Deng X","Zhao X"],"additional_accession":[]},"is_claimable":false,"name":"Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling.","description":"RIG-I/DDX58 plays a key role in host innate immunity. However, its therapeutic potential for inflammation-related cancers remains to be explored. Here we identify frameshift germline mutations of RIG-I occurring in patients with colon cancer. Accordingly, Rig-i<sup>fs/fs</sup> mice bearing a frameshift mutant Rig-i exhibit increased susceptibility to colitis-related colon cancer as well as enhanced inflammatory response to chemical, virus or bacteria. In addition to interruption of Rig-i mRNA translation, the Rig-i mutation changes the secondary structure of Rig-i pre-mRNA and impairs its association with DHX9, consequently inducing a circular RNA generation from Rig-i transcript, thereby, designated as circRIG-I. CircRIG-I is frequently upregulated in colon cancers and its upregulation pr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-27T19:10:59.698Z","creation":"2025-02-19T03:23:18.239Z"},"accession":"S-EPMC9675819","cross_references":{"pubmed":["36402769"],"doi":["10.1038/s41467-022-34885-3"]}}