biostudies-literatureCheng Ythe Belt & Road Programthe Science and Technology Planning Projects of Fuzhouthe Natural Science Foundation of Fujian Provincethe Young and Middle-aged Teacher Education Research Project of Fujian Provincethe Ministry of Science and Technology of Chinathe Science and Technology Planning Projects of Fuzhou Institute of Oceanographythe National Natural Science Foundation of China943-956https://www.ebi.ac.uk/biostudies/studies/S-EPMC9676092biostudies-literatureUnknown23(11)<h4>Objectives</h4>Primary tumor treatment through surgical resection and adjuvant therapy has been extensively studied, but there is a lack of effective strategies and drugs for the treatment of tumor metastases. Here, we describe a functional product based on a combination of compounds, which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases, improving anti-cancer treatment, and enhancing immunity and antioxidant capacity. Our designed combination, named MVBL, consists of four inexpensive compounds: L-selenium-methylselenocysteine (MSC), D-‍α‍-tocopheryl succinic acid (VES), β‍-carotene (β‍-Ca), and L-lysine (Lys).<h4>Methods</h4>The effects of MVBL on cell viability, cell cycle, cell apoptosis, cell migration, cell invasion, reactive oxygeJournal of Zhejiang University. Science. BCombination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy.PMC9676092KXPT-2021-32021S0942015CB93180481961138017 and 817035552021F082021J011046 and 2020J01859JAT200412Zhai SLi SLu YLian SWang JJia LCheng YDeng XfalseCombination of Se-methylselenocysteine, D-α-tocopheryl succinate, β-carotene, and L-lysine can prevent cancer metastases using as an adjuvant therapy.<h4>Objectives</h4>Primary tumor treatment through surgical resection and adjuvant therapy has been extensively studied, but there is a lack of effective strategies and drugs for the treatment of tumor metastases. Here, we describe a functional product based on a combination of compounds, which can be used as an adjuvant therapy and has well-known mechanisms for inhibiting cancer metastases, improving anti-cancer treatment, and enhancing immunity and antioxidant capacity. Our designed combination, named MVBL, consists of four inexpensive compounds: L-selenium-methylselenocysteine (MSC), D-‍α‍-tocopheryl succinic acid (VES), β‍-carotene (β‍-Ca), and L-lysine (Lys).<h4>Methods</h4>The effects of MVBL on cell viability, cell cycle, cell apoptosis, cell migration, cell invasion, reactive oxyge2022-01-01T00:00:00Z2022 Nov2025-04-21T21:28:31.665Z2025-04-05T18:21:48.541ZS-EPMC96760923637961310.1631/jzus.b220023210.1631/jzus.B2200232