{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Zhu L"],"pubmed_abstract":["<i>Arnebiae</i> Radix (dried root of <i>Arnebia euchroma</i> (Royle) Johnst.) is a traditional Chinese medicine (TCM) used to treat macular eruptions, measles, sore throat, carbuncles, burns, skin ulcers, and inflammations. The <i>Arnebiae</i> Radix extract can exert anti-breast cancer effects through various mechanisms of action. This study aimed to rapidly screen potential estrogen receptor (estrogen receptor α and estrogen receptor β) ligands from the <i>Arnebiae</i> Radix extract. In this study, an analytical method based on affinity ultrafiltration coupled with UHPLC-Q-Exactive Orbitrap mass spectrometry was established for rapidly screening and identifying estrogen receptor ligands. Then, bindings of the components to the active site of estrogen receptor (estrogen receptor α and estr"],"journal":["Frontiers in plant science"],"pagination":["1012553"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9676231"],"repository":["biostudies-literature"],"pubmed_title":["Screening and characterization estrogen receptor ligands from <i>Arnebia euchroma</i> (Royle) Johnst. <i>via</i> affinity ultrafiltration LC-MS and molecular docking."],"pmcid":["PMC9676231"],"pubmed_authors":["Wang ZM","Li SN","Zhu L","Liu MJ","Zhang SL","E S","Ma SJ","Li KL","Cai W"],"additional_accession":[]},"is_claimable":false,"name":"Screening and characterization estrogen receptor ligands from <i>Arnebia euchroma</i> (Royle) Johnst. <i>via</i> affinity ultrafiltration LC-MS and molecular docking.","description":"<i>Arnebiae</i> Radix (dried root of <i>Arnebia euchroma</i> (Royle) Johnst.) is a traditional Chinese medicine (TCM) used to treat macular eruptions, measles, sore throat, carbuncles, burns, skin ulcers, and inflammations. The <i>Arnebiae</i> Radix extract can exert anti-breast cancer effects through various mechanisms of action. This study aimed to rapidly screen potential estrogen receptor (estrogen receptor α and estrogen receptor β) ligands from the <i>Arnebiae</i> Radix extract. In this study, an analytical method based on affinity ultrafiltration coupled with UHPLC-Q-Exactive Orbitrap mass spectrometry was established for rapidly screening and identifying estrogen receptor ligands. Then, bindings of the components to the active site of estrogen receptor (estrogen receptor α and estr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T20:33:32.59Z","creation":"2025-04-07T08:29:38.479Z"},"accession":"S-EPMC9676231","cross_references":{"pubmed":["36420029"],"doi":["10.3389/fpls.2022.1012553"]}}