biostudies-literatureUnknown9Liu WNational Natural Science Foundation of China<h4>Background</h4>Sepsis-induced cardiomyopathy (<i>SIC</i>) is one major cause of death for sepsis but lacks timely diagnosis and specific treatment due to unclear mechanisms. Lipocalin-2 (LCN-2) is a key regulator of lipid metabolism which has been recently proved closely related to sepsis, however, the relationship between LCN-2 and septic myocardial injury remains unknown. We aim to explore the role of LCN-2 in the pathological progress of <i>SIC</i> based on clinical and laboratory evidence.<h4>Methods</h4>Consecutive patients admitted to the intensive care unit (ICU) from August 2021 to April 2022 fulfilling the criteria of severe sepsis were included. The level of LCN-2 in plasma was assayed and analyzed with clinical characteristics. Biostatistical analysis was performed for furthFrontiers in cardiovascular medicine1009726https://www.ebi.ac.uk/biostudies/studies/S-EPMC9676239biostudies-literatureLipocalin-2 participates in sepsis-induced myocardial injury by mediating lipid accumulation and mitochondrial dysfunction.PMC9676239Li SGuo XHong TShen YHe BZhang QLiu WJin LSu FfalseLipocalin-2 participates in sepsis-induced myocardial injury by mediating lipid accumulation and mitochondrial dysfunction.<h4>Background</h4>Sepsis-induced cardiomyopathy (<i>SIC</i>) is one major cause of death for sepsis but lacks timely diagnosis and specific treatment due to unclear mechanisms. Lipocalin-2 (LCN-2) is a key regulator of lipid metabolism which has been recently proved closely related to sepsis, however, the relationship between LCN-2 and septic myocardial injury remains unknown. We aim to explore the role of LCN-2 in the pathological progress of <i>SIC</i> based on clinical and laboratory evidence.<h4>Methods</h4>Consecutive patients admitted to the intensive care unit (ICU) from August 2021 to April 2022 fulfilling the criteria of severe sepsis were included. The level of LCN-2 in plasma was assayed and analyzed with clinical characteristics. Biostatistical analysis was performed for furth2022-01-01T00:00:00Z20222026-07-14T17:36:53.298Z2025-04-19T14:44:15.395ZS-EPMC96762393641949110.3389/fcvm.2022.1009726