biostudies-literatureKuhn MSchool of Medicine, Oregon Health and Science UniversityHHS | NIH | National Institute of General Medical SciencesOHSU | Knight Cancer Institute, Oregon Health and Science UniversityNSF | BIO | Division of Biological InfrastructurePrevent Cancer FoundationHHS | NIH | NCI | Basic Research LaboratoryAmerican Cancer SocietyHHS | NIH | National Institute of Diabetes and Digestive and Kidney DiseasesNIDDK NIH HHSAGA Research Foundation (American Gastroenterological AssociationLustgarten FoundationNCI NIH HHSNIGMS NIH HHSG571-G585https://www.ebi.ac.uk/biostudies/studies/S-EPMC9678429biostudies-literatureUnknown323(6)Colorectal cancer (CRC) is a leading cause of cancer-related death. There is an urgent need for new methods of early CRC detection and monitoring to improve patient outcomes. Extracellular vesicles (EVs) are secreted, lipid-bilayer bound, nanoparticles that carry biological cargo throughout the body and in turn exhibit cancer-related biomarker potential. RNA binding proteins (RBPs) are posttranscriptional regulators of gene expression that may provide a link between host cell gene expression and EV phenotypes. Insulin-like growth factor 2 RNA binding protein 1 (IGF2BP1/IMP1) is an RBP that is highly expressed in CRC with higher levels of expression correlating with poor prognosis. IMP1 binds and potently regulates tumor-associated transcripts that may impact CRC EV phenotypes. Our objectivAmerican journal of physiology. Gastrointestinal and liver physiologyIMP1/IGF2BP1 in human colorectal cancer extracellular vesicles.PMC9678429R01 CA243445GM124976F32DK107052CA243445R01 DK124369R01 DK056645R01 DK109714F32 DK107052DK124369R35 GM124976DK1097141936046DK056645Kuhn MLiang SYang JDas SShah PMorita MBlucher AWilliams KNArmstrong RJParham LRMills GZhang WZhang YFavate JMolugu SAndres SFHamilton KEDixon DAMorgan TKPreet RfalseIMP1/IGF2BP1 in human colorectal cancer extracellular vesicles.Colorectal cancer (CRC) is a leading cause of cancer-related death. There is an urgent need for new methods of early CRC detection and monitoring to improve patient outcomes. Extracellular vesicles (EVs) are secreted, lipid-bilayer bound, nanoparticles that carry biological cargo throughout the body and in turn exhibit cancer-related biomarker potential. RNA binding proteins (RBPs) are posttranscriptional regulators of gene expression that may provide a link between host cell gene expression and EV phenotypes. Insulin-like growth factor 2 RNA binding protein 1 (IGF2BP1/IMP1) is an RBP that is highly expressed in CRC with higher levels of expression correlating with poor prognosis. IMP1 binds and potently regulates tumor-associated transcripts that may impact CRC EV phenotypes. Our objectiv2022-01-01T00:00:00Z2022 Dec2025-04-04T09:50:15.496Z2025-02-19T01:17:28.672ZS-EPMC96784293619413110.1152/ajpgi.00121.2022