{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Su N"],"pubmed_abstract":["CD40 and CD154 are one of the best-characterized costimulatory molecules essential for adaptive immunity, which extensively involved in T and B cell activation, IgM Ab production, isotype class switching, germinal center formation and affinity maturation. However, the functionality of CD40 and CD154 in IgZ-mediated immunity remains limited. In this study, we explored the regulatory role of Cd40-Cd154 interaction in IgZ-mediated antibacterial immunity in zebrafish. The results showed that the IgZ-mediated antibacterial response can be significantly induced in response to <i>A. hydrophila</i> infection. The percentage of Cd40<sup>+</sup>IgZ<sup>+</sup> B cells and the production of IgZ Ab were substantially increased upon <i>A. hydrophila</i> stimulation, but these reactions were markedly de"],"journal":["Fish and shellfish Immunology reports"],"pagination":["100038"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680072"],"repository":["biostudies-literature"],"pubmed_title":["Functional role of CD40 and CD154 costimulatory signals in IgZ-mediated immunity against bacterial infection."],"pmcid":["PMC9680072"],"pubmed_authors":["Li H","Fan DD","Su N","Jin CY","Qin LL","Xiang LX","Shao JZ","Hu CB","Shao T","Ji JF","Lin AF"],"additional_accession":[]},"is_claimable":false,"name":"Functional role of CD40 and CD154 costimulatory signals in IgZ-mediated immunity against bacterial infection.","description":"CD40 and CD154 are one of the best-characterized costimulatory molecules essential for adaptive immunity, which extensively involved in T and B cell activation, IgM Ab production, isotype class switching, germinal center formation and affinity maturation. However, the functionality of CD40 and CD154 in IgZ-mediated immunity remains limited. In this study, we explored the regulatory role of Cd40-Cd154 interaction in IgZ-mediated antibacterial immunity in zebrafish. The results showed that the IgZ-mediated antibacterial response can be significantly induced in response to <i>A. hydrophila</i> infection. The percentage of Cd40<sup>+</sup>IgZ<sup>+</sup> B cells and the production of IgZ Ab were substantially increased upon <i>A. hydrophila</i> stimulation, but these reactions were markedly de","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Dec","modification":"2025-04-05T15:21:52.408Z","creation":"2025-04-05T15:21:52.408Z"},"accession":"S-EPMC9680072","cross_references":{"pubmed":["36420488"],"doi":["10.1016/j.fsirep.2021.100038"]}}