biostudies-literatureBlair PWEuropean Union's Framework Programme for Research & InnovationNational Institutes of HealthEuropean Union’s Framework Programme for Research &amp; InnovationNIH HHS869https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680122biostudies-literatureUnknown22(1)<h4>Background</h4>Epidemiology of febrile illness in Uganda is shifting due to increased HIV treatment access, emerging viruses, and increased surveillance. We investigated the aetiology and outcomes of acute febrile illness in adults presenting to hospital using a standardized testing algorithm of available assays in at Arua and Mubende tertiary care hospitals in Uganda.<h4>Methods</h4>We recruited adults with a ≥ 38.0 °C temperature or history of fever within 48 h of presentation from August 2019 to August 2020. Medical history, demographics, and vital signs were recorded. Testing performed included a complete blood count, renal and liver function, malaria smears, blood culture, and human immunodeficiency virus (HIV). When HIV positive, testing included cryptococcal antigen, CD4 count, BMC infectious diseasesAetiology of hospitalized fever and risk of death at Arua and Mubende tertiary care hospitals in Uganda from August 2019 to August 2020.PMC9680122T32 HL116275EDCTP2Lamorde MCandia EMatovu AMayito JBlair PWRobinson MLKobba KNdawula ECAniku GKakooza FKandathil AJManabe YCfalseAetiology of hospitalized fever and risk of death at Arua and Mubende tertiary care hospitals in Uganda from August 2019 to August 2020.<h4>Background</h4>Epidemiology of febrile illness in Uganda is shifting due to increased HIV treatment access, emerging viruses, and increased surveillance. We investigated the aetiology and outcomes of acute febrile illness in adults presenting to hospital using a standardized testing algorithm of available assays in at Arua and Mubende tertiary care hospitals in Uganda.<h4>Methods</h4>We recruited adults with a ≥ 38.0 °C temperature or history of fever within 48 h of presentation from August 2019 to August 2020. Medical history, demographics, and vital signs were recorded. Testing performed included a complete blood count, renal and liver function, malaria smears, blood culture, and human immunodeficiency virus (HIV). When HIV positive, testing included cryptococcal antigen, CD4 count, 2022-01-01T00:00:00Z2022 Nov2025-04-04T22:35:51.598Z2025-04-04T22:35:51.598ZS-EPMC96801223641141510.1186/s12879-022-07877-3