{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Semak V"],"funding":["Government of Lower Austria","Christian Doppler Society"],"pagination":["216"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680258"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["Adsorbents for whole blood apheresis need to be highly blood compatible to minimize the activation of blood cells on the biomaterial surface. Here, we developed blood-compatible matrices by surface modification with polyzwitterionic polysulfobetainic and polycarboxybetainic coatings. Photoreactive zwitterionic terpolymers were synthesized by free-radical polymerization of zwitterionic, photoreactive, and fluorescent monomers. Upon UV irradiation, the terpolymers were photodeposited and mutually crosslinked on the surface of hydrophobic polystyrene-<i>co</i>-divinylbenzene and hydrophilic polyacrylamide-<i>co</i>-polyacrylate (DALI) beads. Fluorescent microscopy revealed coatings with an average thickness of 5 µm, which were limited to the bead surface. Blood compatibility was assessed base"],"journal":["Journal of functional biomaterials"],"pubmed_title":["Polyzwitterionic Coating of Porous Adsorbents for Therapeutic Apheresis."],"pmcid":["PMC9680258"],"funding_grant_id":["Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis","WST3-F-5030664/014-2019","WST3-T-91/042-2016"],"pubmed_authors":["Eichhorn T","Semak V","Weiss R","Weber V"],"additional_accession":[]},"is_claimable":false,"name":"Polyzwitterionic Coating of Porous Adsorbents for Therapeutic Apheresis.","description":"Adsorbents for whole blood apheresis need to be highly blood compatible to minimize the activation of blood cells on the biomaterial surface. Here, we developed blood-compatible matrices by surface modification with polyzwitterionic polysulfobetainic and polycarboxybetainic coatings. Photoreactive zwitterionic terpolymers were synthesized by free-radical polymerization of zwitterionic, photoreactive, and fluorescent monomers. Upon UV irradiation, the terpolymers were photodeposited and mutually crosslinked on the surface of hydrophobic polystyrene-<i>co</i>-divinylbenzene and hydrophilic polyacrylamide-<i>co</i>-polyacrylate (DALI) beads. Fluorescent microscopy revealed coatings with an average thickness of 5 µm, which were limited to the bead surface. Blood compatibility was assessed base","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-05T14:41:21.67Z","creation":"2024-11-20T03:55:18.948Z"},"accession":"S-EPMC9680258","cross_references":{"pubmed":["36412857"],"doi":["10.3390/jfb13040216"]}}