biostudies-literatureSemak VGovernment of Lower AustriaChristian Doppler Society216https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680258biostudies-literatureUnknown13(4)Adsorbents for whole blood apheresis need to be highly blood compatible to minimize the activation of blood cells on the biomaterial surface. Here, we developed blood-compatible matrices by surface modification with polyzwitterionic polysulfobetainic and polycarboxybetainic coatings. Photoreactive zwitterionic terpolymers were synthesized by free-radical polymerization of zwitterionic, photoreactive, and fluorescent monomers. Upon UV irradiation, the terpolymers were photodeposited and mutually crosslinked on the surface of hydrophobic polystyrene-<i>co</i>-divinylbenzene and hydrophilic polyacrylamide-<i>co</i>-polyacrylate (DALI) beads. Fluorescent microscopy revealed coatings with an average thickness of 5 µm, which were limited to the bead surface. Blood compatibility was assessed baseJournal of functional biomaterialsPolyzwitterionic Coating of Porous Adsorbents for Therapeutic Apheresis.PMC9680258Christian Doppler Laboratory for Innovative Therapy Approaches in SepsisWST3-F-5030664/014-2019WST3-T-91/042-2016Eichhorn TSemak VWeiss RWeber VfalsePolyzwitterionic Coating of Porous Adsorbents for Therapeutic Apheresis.Adsorbents for whole blood apheresis need to be highly blood compatible to minimize the activation of blood cells on the biomaterial surface. Here, we developed blood-compatible matrices by surface modification with polyzwitterionic polysulfobetainic and polycarboxybetainic coatings. Photoreactive zwitterionic terpolymers were synthesized by free-radical polymerization of zwitterionic, photoreactive, and fluorescent monomers. Upon UV irradiation, the terpolymers were photodeposited and mutually crosslinked on the surface of hydrophobic polystyrene-<i>co</i>-divinylbenzene and hydrophilic polyacrylamide-<i>co</i>-polyacrylate (DALI) beads. Fluorescent microscopy revealed coatings with an average thickness of 5 µm, which were limited to the bead surface. Blood compatibility was assessed base2022-01-01T00:00:00Z2022 Nov2025-04-05T14:41:21.67Z2024-11-20T03:55:18.948ZS-EPMC96802583641285710.3390/jfb13040216