{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wann ER"],"funding":["NIAID NIH HHS","NHLBI NIH HHS","NIAMS NIH HHS"],"pagination":["4737-43"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC96803"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(9)"],"pubmed_abstract":["Kawasaki disease (KD) is an acute vasculitis of young children that can be complicated by coronary artery abnormalities. Recent findings suggest that a superantigen(s) may play an important role in stimulating the immune activation associated with the disease, although the origin of this superantigen(s) is unclear. Staphylococcus aureus, isolated from the rectum or pharynx of patients with KD, secretes toxic shock syndrome toxin 1 (TSST-1). The KD isolates express low levels of other exoproteins compared to isolates from patients with toxic shock syndrome (TSS). Thus, it was previously suggested that the KD isolates may be defective in the global regulatory locus agr (for accessory gene regulator), which positively regulates these factors (D. Y. M. Leung et al., Lancet 342:1385-1388, 1993)"],"journal":["Infection and immunity"],"pubmed_title":["Staphylococcus aureus isolates from patients with Kawasaki disease express high levels of protein A."],"pmcid":["PMC96803"],"funding_grant_id":["R56 AI020624","AR41256","P01 HL036577","R01 AI020624","HL36577","R01 AR041256","R37 HL037260","HL37260"],"pubmed_authors":["Bina P","Schlievert PM","Leung DY","Fehringer AP","Wann ER","Ezepchuk YV","Hook MM","Reiser RF"],"additional_accession":[]},"is_claimable":false,"name":"Staphylococcus aureus isolates from patients with Kawasaki disease express high levels of protein A.","description":"Kawasaki disease (KD) is an acute vasculitis of young children that can be complicated by coronary artery abnormalities. Recent findings suggest that a superantigen(s) may play an important role in stimulating the immune activation associated with the disease, although the origin of this superantigen(s) is unclear. Staphylococcus aureus, isolated from the rectum or pharynx of patients with KD, secretes toxic shock syndrome toxin 1 (TSST-1). The KD isolates express low levels of other exoproteins compared to isolates from patients with toxic shock syndrome (TSS). Thus, it was previously suggested that the KD isolates may be defective in the global regulatory locus agr (for accessory gene regulator), which positively regulates these factors (D. Y. M. Leung et al., Lancet 342:1385-1388, 1993)","dates":{"release":"1999-01-01T00:00:00Z","publication":"1999 Sep","modification":"2025-05-29T20:26:19.74Z","creation":"2019-03-27T00:16:45Z"},"accession":"S-EPMC96803","cross_references":{"pubmed":["10456925"],"doi":["10.1128/IAI.67.9.4737-4743.1999"]}}