{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(4)"],"submitter":["Markopoulos GS"],"pubmed_abstract":["Human endogenous retroviruses (HERVs) are a family of endogenous retroviruses that comprise the ~8.93% of the human genome sequence, with a high proportion being human specific. The recent expansion of repeated HERV sequences has offered a framework for genetic and epigenetic innovation. In the current report, a systematic approach is implemented to catalogue regulatory elements within HERVs, as a roadmap to potential functions of HERV sequences in gene networks. ENCODE Project has offered a wealth of epigenetic data based on omics technologies. I analyzed the presence of HERV sequences on consensus cis-regulatory elements (cCREs) from ENCODE data. On the one side, HERVs are in 1 out of 9 cCREs (>100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions "],"journal":["Diseases (Basel, Switzerland)"],"pagination":["98"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680359"],"repository":["biostudies-literature"],"pubmed_title":["A Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs)."],"pmcid":["PMC9680359"],"pubmed_authors":["Markopoulos GS"],"additional_accession":[]},"is_claimable":false,"name":"A Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs).","description":"Human endogenous retroviruses (HERVs) are a family of endogenous retroviruses that comprise the ~8.93% of the human genome sequence, with a high proportion being human specific. The recent expansion of repeated HERV sequences has offered a framework for genetic and epigenetic innovation. In the current report, a systematic approach is implemented to catalogue regulatory elements within HERVs, as a roadmap to potential functions of HERV sequences in gene networks. ENCODE Project has offered a wealth of epigenetic data based on omics technologies. I analyzed the presence of HERV sequences on consensus cis-regulatory elements (cCREs) from ENCODE data. On the one side, HERVs are in 1 out of 9 cCREs (>100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T22:14:53.976Z","creation":"2025-04-04T22:14:53.976Z"},"accession":"S-EPMC9680359","cross_references":{"pubmed":["36412592"],"doi":["10.3390/diseases10040098"]}}