biostudies-literatureUnknown10(4)Markopoulos GSHuman endogenous retroviruses (HERVs) are a family of endogenous retroviruses that comprise the ~8.93% of the human genome sequence, with a high proportion being human specific. The recent expansion of repeated HERV sequences has offered a framework for genetic and epigenetic innovation. In the current report, a systematic approach is implemented to catalogue regulatory elements within HERVs, as a roadmap to potential functions of HERV sequences in gene networks. ENCODE Project has offered a wealth of epigenetic data based on omics technologies. I analyzed the presence of HERV sequences on consensus cis-regulatory elements (cCREs) from ENCODE data. On the one side, HERVs are in 1 out of 9 cCREs (>100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions Diseases (Basel, Switzerland)98https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680359biostudies-literatureA Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs).PMC9680359Markopoulos GSfalseA Systems Biology Approach on the Regulatory Footprint of Human Endogenous Retroviruses (HERVs).Human endogenous retroviruses (HERVs) are a family of endogenous retroviruses that comprise the ~8.93% of the human genome sequence, with a high proportion being human specific. The recent expansion of repeated HERV sequences has offered a framework for genetic and epigenetic innovation. In the current report, a systematic approach is implemented to catalogue regulatory elements within HERVs, as a roadmap to potential functions of HERV sequences in gene networks. ENCODE Project has offered a wealth of epigenetic data based on omics technologies. I analyzed the presence of HERV sequences on consensus cis-regulatory elements (cCREs) from ENCODE data. On the one side, HERVs are in 1 out of 9 cCREs (>100.000 cCREs in total), dispersed within the genome and present in cis-regulatory regions 2022-01-01T00:00:00Z2022 Nov2025-04-04T22:14:53.976Z2025-04-04T22:14:53.976ZS-EPMC96803593641259210.3390/diseases10040098