biostudies-literatureGillespie TCNEI NIH HHSNCATS NIH HHS23https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680586biostudies-literatureUnknown63(12)<h4>Purpose</h4>Retinopathy of prematurity (ROP) can lead to blindness. Arachidonic acid (ARA) and docosahexaenoic acid (DHA) regulate retinal inflammation and angiogenesis. The aim of this study was to investigate red blood cell membrane (RBCM) ARA and DHA in preterm infants.<h4>Methods</h4>This prospective observational study divided infants into groups by ROP severity and RBCM ARA and DHA means and terciles.<h4>Results</h4>Although the mean ± SD RBCM ARA was different between groups (no ROP, 17.9% ± 0.7%, vs. type 2 ROP, 17.4% ± 0.8%, vs. type 1 ROP, 16.7% ± 1.0%; P < 0.001), the mean RBCM DHA was similar (P = 0.161). Infants with type 1 ROP were more likely to be in the lowest ARA and DHA terciles than in the highest (ARA, 44% vs. 5.6%; DHA, 22% vs. 5.6%). ARA and DHA declined over theInvestigative ophthalmology & visual scienceDecreased Levels of Erythrocyte Membrane Arachidonic and Docosahexaenoic Acids Are Associated With Retinopathy of Prematurity.PMC9680586KL2 TR000122UL1 TR001881T32 EY007026R01 EY032561Chu ACalkins KLGillespie TCGrogan TKim ESTsui IfalseDecreased Levels of Erythrocyte Membrane Arachidonic and Docosahexaenoic Acids Are Associated With Retinopathy of Prematurity.<h4>Purpose</h4>Retinopathy of prematurity (ROP) can lead to blindness. Arachidonic acid (ARA) and docosahexaenoic acid (DHA) regulate retinal inflammation and angiogenesis. The aim of this study was to investigate red blood cell membrane (RBCM) ARA and DHA in preterm infants.<h4>Methods</h4>This prospective observational study divided infants into groups by ROP severity and RBCM ARA and DHA means and terciles.<h4>Results</h4>Although the mean ± SD RBCM ARA was different between groups (no ROP, 17.9% ± 0.7%, vs. type 2 ROP, 17.4% ± 0.8%, vs. type 1 ROP, 16.7% ± 1.0%; P < 0.001), the mean RBCM DHA was similar (P = 0.161). Infants with type 1 ROP were more likely to be in the lowest ARA and DHA terciles than in the highest (ARA, 44% vs. 5.6%; DHA, 22% vs. 5.6%). ARA and DHA declined over the2022-01-01T00:00:00Z2022 Nov2025-04-25T19:59:24.245Z2025-04-06T08:11:39.713ZS-EPMC96805863638335310.1167/iovs.63.12.23