{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Do T"],"funding":["NIDDK NIH HHS","Rheumatology Research Foundation","Center of Excellence in Molecular Hematology","the Single Cell Phenotyping Core of the Cincinnati Rheumatic Diseases Resource Center","Children's Hospital Research Foundation","National Institutes of Health","NIAMS NIH HHS","the Cincinnati Children's Research Foundation","the Gene Expression Omnibus repository"],"pagination":["71-85"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680651"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["103(1)"],"pubmed_abstract":["Systemic juvenile idiopathic arthritis (SJIA) is a severe childhood arthropathy with features of autoinflammation. Monocytes and macrophages in SJIA have a complex phenotype with both pro- and anti-inflammatory properties that combine features of several well characterized in vitro conditions used to activate macrophages. An important anti-inflammatory phenotype is expression of CD163, a scavenger receptor that sequesters toxic pro-inflammatory complexes that is highly expressed in both active SJIA and macrophage activation syndrome (MAS). CD163 is most strongly up-regulated by IL-10 (M(IL-10)), and not by other conditions that reflect features seen in SJIA monocytes such as M(LPS+IC). MicroRNA plays key roles in integrating cellular signals such as those in macrophage polarization, and as"],"journal":["Journal of leukocyte biology"],"pubmed_title":["MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms."],"pmcid":["PMC9680651"],"funding_grant_id":["P01 AR048929","PO1-AR048929","P30-AR070549","P30 DK090971","P30 AR070549","GSE104853"],"pubmed_authors":["Medvedovic M","Thornton S","Grom AA","Shen N","Bennett M","Schulert GS","Tan R","Do T"],"additional_accession":[]},"is_claimable":false,"name":"MicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms.","description":"Systemic juvenile idiopathic arthritis (SJIA) is a severe childhood arthropathy with features of autoinflammation. Monocytes and macrophages in SJIA have a complex phenotype with both pro- and anti-inflammatory properties that combine features of several well characterized in vitro conditions used to activate macrophages. An important anti-inflammatory phenotype is expression of CD163, a scavenger receptor that sequesters toxic pro-inflammatory complexes that is highly expressed in both active SJIA and macrophage activation syndrome (MAS). CD163 is most strongly up-regulated by IL-10 (M(IL-10)), and not by other conditions that reflect features seen in SJIA monocytes such as M(LPS+IC). MicroRNA plays key roles in integrating cellular signals such as those in macrophage polarization, and as","dates":{"release":"2018-01-01T00:00:00Z","publication":"2018 Jan","modification":"2026-05-27T11:59:34.198Z","creation":"2024-11-13T14:24:47.82Z"},"accession":"S-EPMC9680651","cross_references":{"pubmed":["29345059"],"doi":["10.1002/jlb.2a0317-107r","10.1002/JLB.2A0317-107R"]}}