biostudies-literatureDo TNIDDK NIH HHSRheumatology Research FoundationCenter of Excellence in Molecular Hematologythe Single Cell Phenotyping Core of the Cincinnati Rheumatic Diseases Resource CenterChildren's Hospital Research FoundationNational Institutes of HealthNIAMS NIH HHSthe Cincinnati Children's Research Foundationthe Gene Expression Omnibus repository71-85https://www.ebi.ac.uk/biostudies/studies/S-EPMC9680651biostudies-literatureUnknown103(1)Systemic juvenile idiopathic arthritis (SJIA) is a severe childhood arthropathy with features of autoinflammation. Monocytes and macrophages in SJIA have a complex phenotype with both pro- and anti-inflammatory properties that combine features of several well characterized in vitro conditions used to activate macrophages. An important anti-inflammatory phenotype is expression of CD163, a scavenger receptor that sequesters toxic pro-inflammatory complexes that is highly expressed in both active SJIA and macrophage activation syndrome (MAS). CD163 is most strongly up-regulated by IL-10 (M(IL-10)), and not by other conditions that reflect features seen in SJIA monocytes such as M(LPS+IC). MicroRNA plays key roles in integrating cellular signals such as those in macrophage polarization, and asJournal of leukocyte biologyMicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms.PMC9680651P01 AR048929PO1-AR048929P30-AR070549P30 DK090971P30 AR070549GSE104853Medvedovic MThornton SGrom AAShen NBennett MSchulert GSTan RDo TfalseMicroRNA networks associated with active systemic juvenile idiopathic arthritis regulate CD163 expression and anti-inflammatory functions in macrophages through two distinct mechanisms.Systemic juvenile idiopathic arthritis (SJIA) is a severe childhood arthropathy with features of autoinflammation. Monocytes and macrophages in SJIA have a complex phenotype with both pro- and anti-inflammatory properties that combine features of several well characterized in vitro conditions used to activate macrophages. An important anti-inflammatory phenotype is expression of CD163, a scavenger receptor that sequesters toxic pro-inflammatory complexes that is highly expressed in both active SJIA and macrophage activation syndrome (MAS). CD163 is most strongly up-regulated by IL-10 (M(IL-10)), and not by other conditions that reflect features seen in SJIA monocytes such as M(LPS+IC). MicroRNA plays key roles in integrating cellular signals such as those in macrophage polarization, and as2018-01-01T00:00:00Z2018 Jan2026-05-27T11:59:34.198Z2024-11-13T14:24:47.82ZS-EPMC96806512934505910.1002/jlb.2a0317-107r10.1002/JLB.2A0317-107R