{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gitomer SA"],"funding":["2020 Culshaw Young Investigator Award from the Children&apos;s Hospital Colorado Center for Children&apos;s Surgery","Colorado Clinical and Translational Sciences Institute"],"pagination":["e0277882"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681069"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(11)"],"pubmed_abstract":["<h4>Background</h4>Little is known about olfactory changes in pediatric COVID-19. It is possible that children under-report chemosensory changes on questionnaires, similar to reports in adults. Here, we aim to describe COVID-19-related olfactory dysfunction in outpatient children. We hypothesized that children with COVID-19 will demonstrate abnormal olfaction on smell-identification testing at a higher rate than children with negative COVID-19 testing.<h4>Methods</h4>A prospective cross-sectional study was undertaken from June 2020-June 2021 at a tertiary care pediatric hospital. A consecutive sample of 205 outpatients aged 5-21 years undergoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) PCR testing were approached for this study. Patients with prior olfactory dysfunction were excluded. Participants were given a standard COVID-19 symptom questionnaire, a Smell Identification Test (SIT) and home-odorant-based testing within 2 weeks of COVID-19 testing. Prior to study enrollment, power calculation estimated 42 patients to determine difference in rates of SIT results between groups. Data were summarized with descriptive statistics.<h4>Results</h4>Fifty-one patients underwent smell identification testing (23 positive (45%) and 28 negative (55%) for COVID-19; mean age 12.7 years; 60% female). 92% of all patients denied subjective change in their sense of smell or taste but only 58.8% were normosmic on testing. There was no difference in screening questionnaires or SIT scores between COVID-19 positive and negative groups.<h4>Conclusions</h4>Unlike adults, there was no statistical difference in olfactory function between outpatient COVID-19 positive and negative children. Our findings suggest a discrepancy between objective and patient-reported olfactory function in pediatric patients, and poor performance of current screening protocols at detecting pediatric COVID-19."],"journal":["PloS one"],"pubmed_title":["Olfactory testing as COVID-19 screening in school children; A prospective cross-sectional study."],"pmcid":["PMC9681069"],"funding_grant_id":["2380157","UL1 RR025780"],"pubmed_authors":["Tholen K","Mistry RD","Beswick DM","Pickett K","Herrmann BW","Gitomer SA","Kaar JL"],"additional_accession":[]},"is_claimable":false,"name":"Olfactory testing as COVID-19 screening in school children; A prospective cross-sectional study.","description":"<h4>Background</h4>Little is known about olfactory changes in pediatric COVID-19. It is possible that children under-report chemosensory changes on questionnaires, similar to reports in adults. Here, we aim to describe COVID-19-related olfactory dysfunction in outpatient children. We hypothesized that children with COVID-19 will demonstrate abnormal olfaction on smell-identification testing at a higher rate than children with negative COVID-19 testing.<h4>Methods</h4>A prospective cross-sectional study was undertaken from June 2020-June 2021 at a tertiary care pediatric hospital. A consecutive sample of 205 outpatients aged 5-21 years undergoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) PCR testing were approached for this study. Patients with prior olfactory dysfunction were excluded. Participants were given a standard COVID-19 symptom questionnaire, a Smell Identification Test (SIT) and home-odorant-based testing within 2 weeks of COVID-19 testing. Prior to study enrollment, power calculation estimated 42 patients to determine difference in rates of SIT results between groups. Data were summarized with descriptive statistics.<h4>Results</h4>Fifty-one patients underwent smell identification testing (23 positive (45%) and 28 negative (55%) for COVID-19; mean age 12.7 years; 60% female). 92% of all patients denied subjective change in their sense of smell or taste but only 58.8% were normosmic on testing. There was no difference in screening questionnaires or SIT scores between COVID-19 positive and negative groups.<h4>Conclusions</h4>Unlike adults, there was no statistical difference in olfactory function between outpatient COVID-19 positive and negative children. Our findings suggest a discrepancy between objective and patient-reported olfactory function in pediatric patients, and poor performance of current screening protocols at detecting pediatric COVID-19.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T14:41:22.911Z","creation":"2025-04-05T14:41:22.911Z"},"accession":"S-EPMC9681069","cross_references":{"pubmed":["36413561"],"doi":["10.1371/journal.pone.0277882"]}}