{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Atlas LY"],"funding":["Intramural NIH HHS","NIDA NIH HHS","National Center for Complementary and Integrative Health","National Institute of Mental Health"],"pagination":["e73353"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681218"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["Recent data suggest that interactions between systems involved in higher order knowledge and associative learning drive responses during value-based learning. However, it is unknown how these systems impact subjective responses, such as pain. We tested how instructions and reversal learning influence pain and pain-evoked brain activation. Healthy volunteers (n=40) were either instructed about contingencies between cues and aversive outcomes or learned through experience in a paradigm where contingencies reversed three times. We measured predictive cue effects on pain and heat-evoked brain responses using functional magnetic resonance imaging. Predictive cues dynamically modulated pain perception as contingencies changed, regardless of whether participants received contingency instructions."],"journal":["eLife"],"pubmed_title":["Instructions and experiential learning have similar impacts on pain and pain-related brain responses but produce dissociations in value-based reversal learning."],"pmcid":["PMC9681218"],"funding_grant_id":["ZIA AT000030","ZIA MH002782","ZIAMH-002782","ZIAAT-000030","T32 DA035165"],"pubmed_authors":["Palacios-Barrios EE","Banker LA","Atlas LY","Reynolds RC","Pine DS","Dildine TC","Yu Q","Grant SS"],"additional_accession":[]},"is_claimable":false,"name":"Instructions and experiential learning have similar impacts on pain and pain-related brain responses but produce dissociations in value-based reversal learning.","description":"Recent data suggest that interactions between systems involved in higher order knowledge and associative learning drive responses during value-based learning. However, it is unknown how these systems impact subjective responses, such as pain. We tested how instructions and reversal learning influence pain and pain-evoked brain activation. Healthy volunteers (n=40) were either instructed about contingencies between cues and aversive outcomes or learned through experience in a paradigm where contingencies reversed three times. We measured predictive cue effects on pain and heat-evoked brain responses using functional magnetic resonance imaging. Predictive cues dynamically modulated pain perception as contingencies changed, regardless of whether participants received contingency instructions.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-10T06:35:02.941Z","creation":"2024-11-15T15:39:14.419Z"},"accession":"S-EPMC9681218","cross_references":{"pubmed":["36317867"],"doi":["10.7554/eLife.73353"]}}