biostudies-literatureAtlas LYIntramural NIH HHSNIDA NIH HHSNational Center for Complementary and Integrative HealthNational Institute of Mental Healthe73353https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681218biostudies-literatureUnknown11Recent data suggest that interactions between systems involved in higher order knowledge and associative learning drive responses during value-based learning. However, it is unknown how these systems impact subjective responses, such as pain. We tested how instructions and reversal learning influence pain and pain-evoked brain activation. Healthy volunteers (n=40) were either instructed about contingencies between cues and aversive outcomes or learned through experience in a paradigm where contingencies reversed three times. We measured predictive cue effects on pain and heat-evoked brain responses using functional magnetic resonance imaging. Predictive cues dynamically modulated pain perception as contingencies changed, regardless of whether participants received contingency instructions.eLifeInstructions and experiential learning have similar impacts on pain and pain-related brain responses but produce dissociations in value-based reversal learning.PMC9681218ZIA AT000030ZIA MH002782ZIAMH-002782ZIAAT-000030T32 DA035165Palacios-Barrios EEBanker LAAtlas LYReynolds RCPine DSDildine TCYu QGrant SSfalseInstructions and experiential learning have similar impacts on pain and pain-related brain responses but produce dissociations in value-based reversal learning.Recent data suggest that interactions between systems involved in higher order knowledge and associative learning drive responses during value-based learning. However, it is unknown how these systems impact subjective responses, such as pain. We tested how instructions and reversal learning influence pain and pain-evoked brain activation. Healthy volunteers (n=40) were either instructed about contingencies between cues and aversive outcomes or learned through experience in a paradigm where contingencies reversed three times. We measured predictive cue effects on pain and heat-evoked brain responses using functional magnetic resonance imaging. Predictive cues dynamically modulated pain perception as contingencies changed, regardless of whether participants received contingency instructions.2022-01-01T00:00:00Z2022 Nov2026-05-10T06:35:02.941Z2024-11-15T15:39:14.419ZS-EPMC96812183631786710.7554/eLife.73353