{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Chiang CY"],"funding":["Buddhist Tzu Chi Hospital"],"pubmed_abstract":["Multiple studies show increased severity of SARS-CoV2-infection in patients with comorbidities such as hypertension and diabetes. In this study, we have prepared two herbal-based formulations, a pleiotropic herbal drink (Jin Si Herbal Tea, JHT) and a nasal drop (Jin Si nasal drop, JND), to provide preventive care against SARS-CoV2 infection. The effect of JHT and JND was determined in SARS-CoV2-S-pseudotyped lentivirus-infected bronchial and colorectal cell lines and in SKH-1 mouse models. For preliminary studies, ACE2 receptor abundant bronchial (Calu-3) and colorectal cells (Caco-2) were used to determine the effect of JHT and JND on the host entry of various variants of SARS-CoV2-S-pseudotyped lentivirus. A series of experiments were performed to understand the infection rate in SKH-1 m"],"journal":["Frontiers in pharmacology"],"pagination":["953438"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681529"],"repository":["biostudies-literature"],"pubmed_title":["Combined effect of traditional Chinese herbal-based formulations Jing Si herbal tea and Jing Si nasal drop inhibits adhesion and transmission of SARS-CoV2 in diabetic SKH-1 mice."],"pmcid":["PMC9681529"],"pubmed_authors":["Lin PY","Kuo WW","Chiang CY","Shih CY","Ho TJ","Huang CY","Lin YJ","Lin SZ","Shibu MA","Kuo CH"],"additional_accession":[]},"is_claimable":false,"name":"Combined effect of traditional Chinese herbal-based formulations Jing Si herbal tea and Jing Si nasal drop inhibits adhesion and transmission of SARS-CoV2 in diabetic SKH-1 mice.","description":"Multiple studies show increased severity of SARS-CoV2-infection in patients with comorbidities such as hypertension and diabetes. In this study, we have prepared two herbal-based formulations, a pleiotropic herbal drink (Jin Si Herbal Tea, JHT) and a nasal drop (Jin Si nasal drop, JND), to provide preventive care against SARS-CoV2 infection. The effect of JHT and JND was determined in SARS-CoV2-S-pseudotyped lentivirus-infected bronchial and colorectal cell lines and in SKH-1 mouse models. For preliminary studies, ACE2 receptor abundant bronchial (Calu-3) and colorectal cells (Caco-2) were used to determine the effect of JHT and JND on the host entry of various variants of SARS-CoV2-S-pseudotyped lentivirus. A series of experiments were performed to understand the infection rate in SKH-1 m","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T04:24:43.643Z","creation":"2025-04-19T04:24:43.643Z"},"accession":"S-EPMC9681529","cross_references":{"pubmed":["36425575"],"doi":["10.3389/fphar.2022.953438"]}}