{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang F"],"funding":["Natural Science Foundation of Zhejiang Province"],"pagination":["1630260"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681548"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["This study aimed to investigate the molecular mechanisms of microRNA-146a (miR-146a) on gingival mesenchymal stem cells (MSCs). Gingival MSCs were isolated from the gingiva tissues of patients with periodontal disease to reveal the function of miR-146a in regulating osteoblast differentiation. miR-146a inhibits osteoblast differentiation by inhibiting phosphorylated cyclic-AMP response binding (CREB) protein translocation into the nucleus and ultimately attenuating runt-related transcription factor 2 (Runx2) expression. Furthermore, silencing miR-146a promotes the proliferation of gingival MSCs. Of note, targeted inhibition of miR-146a also inhibited LPS-induced inflammatory response and promoted the proliferation of gingival MSCs via CREB/Runx2 axis. MiR-146a is a key negative regulator o"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells."],"pmcid":["PMC9681548"],"funding_grant_id":["2020386978","LY18C100001"],"pubmed_authors":["Li X","Jing Z","Wei T","Jiang H","Wang F"],"additional_accession":[]},"is_claimable":false,"name":"Study on the Mechanism of miR-146a in Gingival Mesenchymal Stem Cells.","description":"This study aimed to investigate the molecular mechanisms of microRNA-146a (miR-146a) on gingival mesenchymal stem cells (MSCs). Gingival MSCs were isolated from the gingiva tissues of patients with periodontal disease to reveal the function of miR-146a in regulating osteoblast differentiation. miR-146a inhibits osteoblast differentiation by inhibiting phosphorylated cyclic-AMP response binding (CREB) protein translocation into the nucleus and ultimately attenuating runt-related transcription factor 2 (Runx2) expression. Furthermore, silencing miR-146a promotes the proliferation of gingival MSCs. Of note, targeted inhibition of miR-146a also inhibited LPS-induced inflammatory response and promoted the proliferation of gingival MSCs via CREB/Runx2 axis. MiR-146a is a key negative regulator o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-25T20:32:51.408Z","creation":"2025-04-06T08:23:45.232Z"},"accession":"S-EPMC9681548","cross_references":{"pubmed":["36425259"],"doi":["10.1155/2022/1630260"]}}