{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(11)"],"submitter":["Natrus L"],"pubmed_abstract":["<h4>Background</h4>Hypothalamic dysregulation may cause abnormal glucose metabolism and type 2 diabetes mellitus (T2DM). The balance between autophagy and apoptosis is important for maintaining cellular/tissue homeostasis and may be disrupted in T2DM.<h4>Objectives</h4>Since propionic acid (PA) exerts neuroprotective effects, the aim was to investigate its effects on apoptosis/autophagy switch in the ventromedial hypothalamus (VMH) of T2DM rats.<h4>Materials and methods</h4>Male Wistar rats were divided: 1) control; 2) T2DM; groups that received (14 days, orally): 3) metformin (60 mg/kg); 4) sodium salt of PA (60 mg/kg); 5) PA + metformin. Western blotting (Bax, Bcl-xl, LC3, Beclin-1, caspase-3), RT-PCR (Bax, Bcl-xl, LC3, Beclin-1), transmission electron microscopy and immunohistochemical "],"journal":["Heliyon"],"pagination":["e11529"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681650"],"repository":["biostudies-literature"],"pubmed_title":["Regulation of the apoptosis/autophagy switch by propionic acid in ventromedial hypothalamus of rats with type 2 diabetes mellitus."],"pmcid":["PMC9681650"],"pubmed_authors":["Osadchuk Y","Klys Y","Chaikovsky Y","Labudzynskyi D","Lisakovska O","Natrus L","Babel N","Roch T"],"additional_accession":[]},"is_claimable":false,"name":"Regulation of the apoptosis/autophagy switch by propionic acid in ventromedial hypothalamus of rats with type 2 diabetes mellitus.","description":"<h4>Background</h4>Hypothalamic dysregulation may cause abnormal glucose metabolism and type 2 diabetes mellitus (T2DM). The balance between autophagy and apoptosis is important for maintaining cellular/tissue homeostasis and may be disrupted in T2DM.<h4>Objectives</h4>Since propionic acid (PA) exerts neuroprotective effects, the aim was to investigate its effects on apoptosis/autophagy switch in the ventromedial hypothalamus (VMH) of T2DM rats.<h4>Materials and methods</h4>Male Wistar rats were divided: 1) control; 2) T2DM; groups that received (14 days, orally): 3) metformin (60 mg/kg); 4) sodium salt of PA (60 mg/kg); 5) PA + metformin. Western blotting (Bax, Bcl-xl, LC3, Beclin-1, caspase-3), RT-PCR (Bax, Bcl-xl, LC3, Beclin-1), transmission electron microscopy and immunohistochemical ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-21T16:12:16.753Z","creation":"2025-04-21T16:12:16.753Z"},"accession":"S-EPMC9681650","cross_references":{"pubmed":["36439719"],"doi":["10.1016/j.heliyon.2022.e11529"]}}