biostudies-literatureO'Hearn MU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood InstituteU.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)7066https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681774biostudies-literatureUnknown13(1)The Food Compass is a nutrient profiling system (NPS) to characterize the healthfulness of diverse foods, beverages and meals. In a nationally representative cohort of 47,999 U.S. adults, we validated a person's individual Food Compass Score (i.FCS), ranging from 1 (least healthful) to 100 (most healthful) based on cumulative scores of items consumed, against: (a) the Healthy Eating Index (HEI) 2015; (b) clinical risk factors and health conditions; and (c) all-cause mortality. Nationally, the mean (SD) of i.FCS was 35.5 (10.9). i.FCS correlated highly with HEI-2015 (R = 0.81). After multivariable-adjustment, each one SD (10.9 point) higher i.FCS associated with more favorable BMI (-0.60 kg/m² [-0.70,-0.51]), systolic blood pressure (-0.69 mmHg [-0.91,-0.48]), diastolic blood preNature communicationsValidation of Food Compass with a healthy diet, cardiometabolic health, and mortality among U.S. adults, 1999-2018.PMC96817742R01HL115189Economos CWong JBBlumberg JBErndt-Marino JO'Hearn MLauren BNMozaffarian DGerber SfalseValidation of Food Compass with a healthy diet, cardiometabolic health, and mortality among U.S. adults, 1999-2018.The Food Compass is a nutrient profiling system (NPS) to characterize the healthfulness of diverse foods, beverages and meals. In a nationally representative cohort of 47,999 U.S. adults, we validated a person's individual Food Compass Score (i.FCS), ranging from 1 (least healthful) to 100 (most healthful) based on cumulative scores of items consumed, against: (a) the Healthy Eating Index (HEI) 2015; (b) clinical risk factors and health conditions; and (c) all-cause mortality. Nationally, the mean (SD) of i.FCS was 35.5 (10.9). i.FCS correlated highly with HEI-2015 (R = 0.81). After multivariable-adjustment, each one SD (10.9 point) higher i.FCS associated with more favorable BMI (-0.60 kg/m² [-0.70,-0.51]), systolic blood pressure (-0.69 mmHg [-0.91,-0.48]), diastolic blood pre2022-01-01T00:00:00Z2022 Nov2025-04-25T21:03:10.088Z2025-04-06T08:33:34.158ZS-EPMC96817743641461910.1038/s41467-022-34195-8