biostudies-literatureOchs-Balcom HMNHLBI NIH HHSNCI NIH HHSU.S. Department of Health &amp; Human Services | National Institutes of Health1983-1990https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681872biostudies-literatureUnknown127(11)<h4>Background</h4>Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race.<h4>Methods</h4>We evaluated body mass index (BMI) and invasive epithelial ovarian cancer (EOC) risk in a pooled study of case-control and nested case-control studies including AA and White women. We evaluated both young adult and recent BMI (within the last 5 years). Associations were estimated using multi-level and multinomial logistic regression models.<h4>Results</h4>The sample included 1078 AA cases, 2582 AA controls, 3240 White cases and 9851 White controls. We observed a higher risk for the non-high-grade serous (NHGS) histotypes for AA women with obesity (OR_{BMI 30+}= 1.62, 95% CIBritish journal of cancerRacial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.PMC9681872R01 CA076016U01 CA164974R01-CA142081R01 CA207260R01-CA058420UM1 CA173642P30 CA014089R01-CA076016UM1-CA164974HHSN268201600002CUM1 CA164974HHSN268201600003CR01-CA207260K01 CA212056U01-CA164974R01 CA058598HHSN268201600001CR01 CA058420R01-CA17054HHSN268201600018CHHSN268201600004CK01-CA212056R01-CA58598R01 CA142081Myers ESchildkraut JMOchs-Balcom HMJoslin CEBethea TNDempsey LFRosenow WBandera EVCamacho FPeres LCGuertin KABeeghly-Fadiel AWu AHMoorman PGWendy Setiawan VRosenberg LJohnson CHarris HRQin BfalseRacial differences in the association of body mass index and ovarian cancer risk in the OCWAA Consortium.<h4>Background</h4>Obesity disproportionately affects African American (AA) women and has been shown to increase ovarian cancer risk, with some suggestions that the association may differ by race.<h4>Methods</h4>We evaluated body mass index (BMI) and invasive epithelial ovarian cancer (EOC) risk in a pooled study of case-control and nested case-control studies including AA and White women. We evaluated both young adult and recent BMI (within the last 5 years). Associations were estimated using multi-level and multinomial logistic regression models.<h4>Results</h4>The sample included 1078 AA cases, 2582 AA controls, 3240 White cases and 9851 White controls. We observed a higher risk for the non-high-grade serous (NHGS) histotypes for AA women with obesity (OR_{BMI 30+}= 1.62, 95% CI2022-01-01T00:00:00Z2022 Nov2026-07-14T15:35:08.631Z2025-04-20T03:27:52.954ZS-EPMC96818723613807110.1038/s41416-022-01981-6