biostudies-literatureUnknown10(2)Ghotbi JMinimally invasive pancreatoduodenectomy has gained popularity throughout the last decade. For laparoscopic pancreatoduodenectomy, some high-level evidence exists, but with conflicting results. There are currently no published randomized controlled trials comparing robotic and open pancreatoduodenectomy. Comparative long-term data for patients with pancreatic ductal adenocarcinoma is lacking to date. Based on the existing evidence, current observed benefits of minimally invasive pancreatoduodenectomy over open pancreatoduodenectomy seem scarce, but retrospective data indicate the safety of these procedures in selected patients. As familiarity with the robotic platform increases, studies have shown an expansion in indications, also including patients with vascular involvement and even indicOncology and therapy301-315https://www.ebi.ac.uk/biostudies/studies/S-EPMC9681949biostudies-literatureMinimally Invasive Pancreatoduodenectomy: Contemporary Practice, Evidence, and Knowledge Gaps.PMC9681949Labori KJGhotbi JFretland AARosok BYaqub STholfsen TKleive DWaage ASahakyan MSoreide KEdwin BfalseMinimally Invasive Pancreatoduodenectomy: Contemporary Practice, Evidence, and Knowledge Gaps.Minimally invasive pancreatoduodenectomy has gained popularity throughout the last decade. For laparoscopic pancreatoduodenectomy, some high-level evidence exists, but with conflicting results. There are currently no published randomized controlled trials comparing robotic and open pancreatoduodenectomy. Comparative long-term data for patients with pancreatic ductal adenocarcinoma is lacking to date. Based on the existing evidence, current observed benefits of minimally invasive pancreatoduodenectomy over open pancreatoduodenectomy seem scarce, but retrospective data indicate the safety of these procedures in selected patients. As familiarity with the robotic platform increases, studies have shown an expansion in indications, also including patients with vascular involvement and even indic2022-01-01T00:00:00Z2022 Dec2025-04-18T20:32:32.937Z2025-04-07T08:25:06.515ZS-EPMC96819493582993310.1007/s40487-022-00203-6