biostudies-literatureUnknown13Wang YC<h4>Background and aims</h4>Epidemiological studies have been conducted on the relationship between systemic rheumatic diseases (SRDs) and dementia. Therefore, we focused on determining the extent of alliances bounded by SRDs, along with the risk of dementia.<h4>Materials and methods</h4>Two independent reviewers assessed all studies retrieved from the PubMed, EMBASE, Scopus, and Web of Science databases between January 1, 2000 and November 30, 2021. Only observational studies that estimated the possibility of dementia in participants with SRD were considered. The random-effects model was applied to forecast pooled risk ratios (RRs) and 95% confidence intervals (CI). Heterogeneity among the studies was evaluated using the Q and I² statistics. The quality of the included studies Frontiers in immunology1054246https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682025biostudies-literatureAssociation between systemic rheumatic diseases and dementia risk: A meta-analysis.PMC9682025Huang APKung WMWang YCWu CCLin MSfalseAssociation between systemic rheumatic diseases and dementia risk: A meta-analysis.<h4>Background and aims</h4>Epidemiological studies have been conducted on the relationship between systemic rheumatic diseases (SRDs) and dementia. Therefore, we focused on determining the extent of alliances bounded by SRDs, along with the risk of dementia.<h4>Materials and methods</h4>Two independent reviewers assessed all studies retrieved from the PubMed, EMBASE, Scopus, and Web of Science databases between January 1, 2000 and November 30, 2021. Only observational studies that estimated the possibility of dementia in participants with SRD were considered. The random-effects model was applied to forecast pooled risk ratios (RRs) and 95% confidence intervals (CI). Heterogeneity among the studies was evaluated using the Q and I² statistics. The quality of the included studies 2022-01-01T00:00:00Z20222025-04-21T16:11:55.328Z2025-04-21T16:11:55.328ZS-EPMC96820253643914110.3389/fimmu.2022.1054246