{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Herrera-Heredia SA"],"funding":["Ministry of Science and Technology, Taiwan","Yen Tjing Ling Medical Foundation"],"pagination":["1000405"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682282"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Mast cells are innate immune cells strategically positioned around blood vessels near body surfaces. Their primary weapons are bioactive amines, mast cell-specific proteases, and cytokines stored in preformed granules. Mast cells granules constituents are packaged efficiently with the help of the highly negatively charged Heparan sulfate-derivative, Heparin. Heparin is one of the most widely used drugs to treat coagulation disorders, yet, it is not found in the circulation at a steady state, casting doubt that the prevention of blood clotting is its physiological function. Early studies using <i>Ndst2</i> <sup>-/-</sup> mice have shown that Heparin is essential for mast cells granules formation. However, these mice could still produce less sulfated Heparan sulfate that could potentially re"],"journal":["Frontiers in immunology"],"pubmed_title":["Heparin is required for the formation of granules in connective tissue mast cells."],"pmcid":["PMC9682282"],"funding_grant_id":["106-2320-B-010- 026-MY3, 107-2320-B-010-016-MY3, 110-2320-B-A49A-521 –","CI-107-6, CI-108-5, CI-111-6"],"pubmed_authors":["Herrera-Heredia SA","Tsai YH","Roers A","Kao CY","Hsu CL","Hsu HP","Yamaguchi Y","Dzhagalov IL"],"additional_accession":[]},"is_claimable":false,"name":"Heparin is required for the formation of granules in connective tissue mast cells.","description":"Mast cells are innate immune cells strategically positioned around blood vessels near body surfaces. Their primary weapons are bioactive amines, mast cell-specific proteases, and cytokines stored in preformed granules. Mast cells granules constituents are packaged efficiently with the help of the highly negatively charged Heparan sulfate-derivative, Heparin. Heparin is one of the most widely used drugs to treat coagulation disorders, yet, it is not found in the circulation at a steady state, casting doubt that the prevention of blood clotting is its physiological function. Early studies using <i>Ndst2</i> <sup>-/-</sup> mice have shown that Heparin is essential for mast cells granules formation. However, these mice could still produce less sulfated Heparan sulfate that could potentially re","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-21T18:59:52.101Z","creation":"2025-04-05T17:29:12.173Z"},"accession":"S-EPMC9682282","cross_references":{"pubmed":["36439118"],"doi":["10.3389/fimmu.2022.1000405"]}}