biostudies-literatureVakil AUCrohn's and Colitis Foundation5199-5209https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682482biostudies-literatureUnknown5(11)Chronic wounds can remain open for several months and have high risks of amputation due to infection. Dressing materials to treat chronic wounds should be conformable for irregular wound geometries, maintain a moist wound bed, and reduce infection risks. To that end, we developed cytocompatible shape memory polyurethane-based poly(ethylene glycol) (PEG) hydrogels that allow facile delivery to the wound site. Plant-based phenolic acids were physically incorporated onto the hydrogel scaffolds to provide antimicrobial properties. These materials were tested to confirm their shape memory properties, cytocompatibility, and antibacterial properties. The incorporation of phenolic acids provides a new mechanism for tuning intermolecular bonding in the hydrogels and corollary mechanical and shape mACS applied bio materialsAntimicrobial Shape Memory Polymer Hydrogels for Chronic Wound Dressings.PMC9682482649526Vakil AURamezani MMonroe MBBfalseAntimicrobial Shape Memory Polymer Hydrogels for Chronic Wound Dressings.Chronic wounds can remain open for several months and have high risks of amputation due to infection. Dressing materials to treat chronic wounds should be conformable for irregular wound geometries, maintain a moist wound bed, and reduce infection risks. To that end, we developed cytocompatible shape memory polyurethane-based poly(ethylene glycol) (PEG) hydrogels that allow facile delivery to the wound site. Plant-based phenolic acids were physically incorporated onto the hydrogel scaffolds to provide antimicrobial properties. These materials were tested to confirm their shape memory properties, cytocompatibility, and antibacterial properties. The incorporation of phenolic acids provides a new mechanism for tuning intermolecular bonding in the hydrogels and corollary mechanical and shape m2022-01-01T00:00:00Z2022 Nov2025-04-18T17:06:46.734Z2025-04-07T04:40:15.106ZS-EPMC96824823625705310.1021/acsabm.2c00617