{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Behymer MM"],"funding":["National Institute of Neurological Disorders and Stroke","National Cancer Institute","U.S. Department of Education"],"pagination":["1983-1996"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682522"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["35(11)"],"pubmed_abstract":["The development of rapidly acting cyanide countermeasures using intramuscular injection (IM) represents an unmet medical need to mitigate toxicant exposures in mass casualty settings. Previous work established that cisplatin and other platinum(II) or platinum(IV)-based agents effectively mitigate cyanide toxicity in zebrafish. Cyanide's <i>in vivo</i> reaction with platinum-containing materials was proposed to reduce the risk of acute toxicities. However, cyanide antidote activity depended on a formulation of platinum-chloride salts with dimethyl sulfoxide (DMSO) followed by dilution in phosphate-buffered saline (PBS). A working hypothesis to explain the DMSO requirement is that the formation of platinum-sulfoxide complexes activates the cyanide scavenging properties of platinum. Preparati"],"journal":["Chemical research in toxicology"],"pubmed_title":["Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures."],"pmcid":["PMC9682522"],"funding_grant_id":["P200A150136","P30 CA023168","U54NS112107"],"pubmed_authors":["Mahon SB","Behymer MM","Suresh V","Chan A","Lee J","Fujii N","Mo H","Boss GR","MacRae CA","Knipp GT","Davisson VJ","Peterson R","Saha K","Nath AK","Brenner M"],"additional_accession":[]},"is_claimable":false,"name":"Identification of Platinum(II) Sulfide Complexes Suitable as Intramuscular Cyanide Countermeasures.","description":"The development of rapidly acting cyanide countermeasures using intramuscular injection (IM) represents an unmet medical need to mitigate toxicant exposures in mass casualty settings. Previous work established that cisplatin and other platinum(II) or platinum(IV)-based agents effectively mitigate cyanide toxicity in zebrafish. Cyanide's <i>in vivo</i> reaction with platinum-containing materials was proposed to reduce the risk of acute toxicities. However, cyanide antidote activity depended on a formulation of platinum-chloride salts with dimethyl sulfoxide (DMSO) followed by dilution in phosphate-buffered saline (PBS). A working hypothesis to explain the DMSO requirement is that the formation of platinum-sulfoxide complexes activates the cyanide scavenging properties of platinum. Preparati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-18T14:59:41.239Z","creation":"2025-04-07T01:24:19.721Z"},"accession":"S-EPMC9682522","cross_references":{"pubmed":["36201358"],"doi":["10.1021/acs.chemrestox.2c00157"]}}