{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(52)"],"submitter":["Michalek S"],"pubmed_abstract":["Herein, we describe the development of a green, scalable flow Pd-catalyzed aerobic oxidation for the key step in the synthesis of CPL302415, which is a new PI3K<i>δ</i> inhibitor. Applying this environmental-friendly, sustainable catalytic oxidation we significantly increased product yield (up to 84%) and by eliminating of workup step, we improved the waste index and E factor (up to 0.13) in comparison with the stoichiometric synthesis. The process was optimized by using the DoE approach."],"journal":["RSC advances"],"pagination":["33605-33611"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682622"],"repository":["biostudies-literature"],"pubmed_title":["The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415)."],"pmcid":["PMC9682622"],"pubmed_authors":["Dubiel K","Wieczorek M","Zagozda M","Michalek S","Maruszak W","Maj AM","Ochal Z","Gurba-Bryskiewicz L"],"additional_accession":[]},"is_claimable":false,"name":"The design of experiments (DoE) in optimization of an aerobic flow Pd-catalyzed oxidation of alcohol towards an important aldehyde precursor in the synthesis of phosphatidylinositide 3-kinase inhibitor (CPL302415).","description":"Herein, we describe the development of a green, scalable flow Pd-catalyzed aerobic oxidation for the key step in the synthesis of CPL302415, which is a new PI3K<i>δ</i> inhibitor. Applying this environmental-friendly, sustainable catalytic oxidation we significantly increased product yield (up to 84%) and by eliminating of workup step, we improved the waste index and E factor (up to 0.13) in comparison with the stoichiometric synthesis. The process was optimized by using the DoE approach.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2024-10-19T00:54:23.444Z","creation":"2024-10-19T00:54:23.444Z"},"accession":"S-EPMC9682622","cross_references":{"pubmed":["36505705"],"doi":["10.1039/d2ra07003k"]}}