{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(1)"],"submitter":["Herzog C"],"funding":["The Eve Appeal"],"pubmed_abstract":["Cervical screening using primary human papilloma virus (HPV) testing and cytology is being implemented in several countries. Cytology as triage for colposcopy referral suffers from several shortcomings. HPV testing overcomes some of these but lacks specificity in women under 30. Here, we aimed to develop and validate an automatable triage test that is highly sensitive and specific independently of age and sample heterogeneity, and predicts progression to CIN3+ in HPV+ patients. The WID™-qCIN, assessing three regions in human genes DPP6, RALYL, and GSX1, was validated in both a diagnostic (case-control) and predictive setting (nested case-control), in a total of 761 samples. Using a predefined threshold, the sensitivity of the WID™-qCIN test was 100% and 78% to detect invasive cancer and CI"],"journal":["Clinical epigenetics"],"pagination":["150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682674"],"repository":["biostudies-literature"],"pubmed_title":["DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test."],"pmcid":["PMC9682674"],"pubmed_authors":["Sroczynski G","Dostalek L","Cibula D","Siebert U","Evans I","Redl E","Jones A","Wang J","Sundstrom K","Barrett JE","Dillner J","Widschwendter M","Paytubi S","Zikan M","Costas L","Herzog C","Schreiberhuber L"],"additional_accession":[]},"is_claimable":false,"name":"DNA methylation-based detection and prediction of cervical intraepithelial neoplasia grade 3 and invasive cervical cancer with the WID™-qCIN test.","description":"Cervical screening using primary human papilloma virus (HPV) testing and cytology is being implemented in several countries. Cytology as triage for colposcopy referral suffers from several shortcomings. HPV testing overcomes some of these but lacks specificity in women under 30. Here, we aimed to develop and validate an automatable triage test that is highly sensitive and specific independently of age and sample heterogeneity, and predicts progression to CIN3+ in HPV+ patients. The WID™-qCIN, assessing three regions in human genes DPP6, RALYL, and GSX1, was validated in both a diagnostic (case-control) and predictive setting (nested case-control), in a total of 761 samples. Using a predefined threshold, the sensitivity of the WID™-qCIN test was 100% and 78% to detect invasive cancer and CI","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T22:35:46.966Z","creation":"2025-04-04T22:35:46.966Z"},"accession":"S-EPMC9682674","cross_references":{"pubmed":["36414968"],"doi":["10.1186/s13148-022-01353-0"]}}