{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["22(1)"],"submitter":["Manzini PM"],"pubmed_abstract":["<h4>Background</h4>The efficacy of early treatment with convalescent plasma in patients with COVID-19 is debated. Nothing is known about the potential effect of other plasma components other than anti-SARS-CoV-2 antibodies.<h4>Methods</h4>To determine whether convalescent or standard plasma would improve outcomes for adults in early phase of Covid19 respiratory impairment we designed this randomized, three-arms, clinical trial (PLACO COVID) blinded on interventional arms that was conducted from June 2020 to August 2021. It was a multicentric trial at 19 Italian hospitals. We enrolled 180 hospitalized adult patients with COVID-19 pneumonia within 5 days from the onset of respiratory distress. Patients were randomly assigned in a 1:1:1 ratio to standard of care (n = 60) or standard of care +"],"journal":["BMC infectious diseases"],"pagination":["879"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682750"],"repository":["biostudies-literature"],"pubmed_title":["Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial."],"pmcid":["PMC9682750"],"pubmed_authors":["Sini BL","Longa LA","Lemut F","Grillo M","Bertone S","Aguzzi C","Milia MG","Avolio M","Russo A","Racca F","Di Perri G","De Rosa A","Molino P","Pelazza C","Liccardi MM","Baffa A","Apra F","Chinaglia A","Hu H","Scozzari G","D'Amato T","Ghiotto S","Liuzzi N","Lucania G","Del Bono V","Patti F","Mazzucco L","Vitale F","Poggio GA","Prina M","Montagnani L","Vallino D","Gurioli L","Granero V","Navarra M","Montagnana M","Canepari M","Berti P","Valfre A","De Martino D","Pomero F","Torti P","Varese P","Magro E","Ottone P","Pittaluga F","Marmifero M","Avdis C","Meucci M","Mattei A","Macchi S","Danielle F","Aluffi E","Pellu V","Monge E","Ruscitto L","Birocco N","Castenetto E","Converso M","Maddalena L","Magnani S","Novelli M","Tavera S","Camerini O","Romano D","Castiglione A","Ravera E","Piovano F","Pastorelli M","Eliantonio F","Gregoretti MG","PLACO COVID Study Group","Franza O","Brazzi L","Scapino B","Veglio MG","Ferro F","Salio M","Ricotti M","Buffolo F","Semino G","Manno E","Roberti G","Ciccone G","Giachino O","Pellegrino MC","Labanca L","Nico V","Scaglione L","Crocilla C","Balduzzi G","Guido G","Caula G","Cornagliotto G","Doveri G","Costa C","Bergamo D","Ongaro D","Ratti D","Gianotto G","Delios G","Canta F","Solimine C","Nucci A","Messa E","Ocello P","Sacchetti P","Segala V","Prucca M","Guaschino R","Leoncino S","Meinardi S","Scuvera ITD","De Micheli AG","Gianarda M","Avonto I","Galassi C","Raso S","Ziccardi S","Giustetto G","Norbiato C","Albera C","Pinna SM","Gallo V","Napoli F","Camisasca G","Pavan A","Rizzioli G","Frascaroli C","Artoni P","Albiani R","Formica M","De Rosa FG","Aldieri C","Buono G","Cavallo R","Bordiga AM","Giancaspero K","Mitola B","Benedetti V","Perboni A","Russo ML","Vitali E","Aiosa G","Grandinetti V","D'Antico S","Baldassano S","Pagnozzi F","Ciardiello A","Pasquino P","Gravante U","Pagliarino M","Naselli S","Barzaghi N","Girino M","Blangetti I","Radin E","Francisci T","Arena F","Vivenza DML","Pollis F","Ambrogio L","Scabini S","Gardini I","Tornello A","Chichino G","Lutri L","Ghiazza G","Cianci MG","Ghisetti V","Pecoraro C","Prota R","Daffonchio A","Beltramo T","Santamaria GM","Gilestro C","Fassiola A","Tucciarone M","Balbo R","Lorenzi M","Saccona F","Balbo V","Scaglia C","Noe E","Chiappero C","Vischia F","Perotti L","Roncato R","Milan M","Calosso L","Locatelli A","Manzini PM","Freilone R","Palladino A","Livigni S","Caironi P","Libanore V","Boverio R","Lupo C","Gamna F","Lorenzelli L","Spidalieri P","Marletto FP","Castagno F","Calcagno A","Fiore G","Strani G","Lupia E","La Grotta R"],"additional_accession":[]},"is_claimable":false,"name":"Convalescent or standard plasma versus standard of care in the treatment of COVID-19 patients with respiratory impairment: short and long-term effects. A three-arm randomized controlled clinical trial.","description":"<h4>Background</h4>The efficacy of early treatment with convalescent plasma in patients with COVID-19 is debated. Nothing is known about the potential effect of other plasma components other than anti-SARS-CoV-2 antibodies.<h4>Methods</h4>To determine whether convalescent or standard plasma would improve outcomes for adults in early phase of Covid19 respiratory impairment we designed this randomized, three-arms, clinical trial (PLACO COVID) blinded on interventional arms that was conducted from June 2020 to August 2021. It was a multicentric trial at 19 Italian hospitals. We enrolled 180 hospitalized adult patients with COVID-19 pneumonia within 5 days from the onset of respiratory distress. Patients were randomly assigned in a 1:1:1 ratio to standard of care (n = 60) or standard of care +","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-28T20:54:24.594Z","creation":"2024-12-03T16:22:03.824Z"},"accession":"S-EPMC9682750","cross_references":{"pubmed":["36418984"],"doi":["10.1186/s12879-022-07716-5"]}}