{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tu PHT"],"funding":["Fonds Wetenschappelijk Onderzoek"],"pagination":["876"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682818"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["<h4>Background</h4>Bedaquiline (BDQ) is a core drug for rifampicin-resistant tuberculosis (RR-TB) treatment. Accurate prediction of a BDQ-resistant phenotype from genomic data is not yet possible. A Bayesian method to predict BDQ resistance probability from next-generation sequencing data has been proposed as an alternative.<h4>Methods</h4>We performed a qualitative study to investigate the decision-making of physicians when facing different levels of BDQ resistance probability. Fourteen semi-structured interviews were conducted with physicians experienced in treating RR-TB, sampled purposefully from eight countries with varying income levels and burden of RR-TB. Five simulated patient scenarios were used as a trigger for discussion. Factors influencing the decision of physicians to prescr"],"journal":["BMC infectious diseases"],"pubmed_title":["Bedaquiline resistance probability to guide treatment decision making for rifampicin-resistant tuberculosis: insights from a qualitative study."],"pmcid":["PMC9682818"],"funding_grant_id":["G0F8316N"],"pubmed_authors":["Loos J","Dippenaar A","Conceicao EC","Tu PHT","Anlay DZ","Van Rie A"],"additional_accession":[]},"is_claimable":false,"name":"Bedaquiline resistance probability to guide treatment decision making for rifampicin-resistant tuberculosis: insights from a qualitative study.","description":"<h4>Background</h4>Bedaquiline (BDQ) is a core drug for rifampicin-resistant tuberculosis (RR-TB) treatment. Accurate prediction of a BDQ-resistant phenotype from genomic data is not yet possible. A Bayesian method to predict BDQ resistance probability from next-generation sequencing data has been proposed as an alternative.<h4>Methods</h4>We performed a qualitative study to investigate the decision-making of physicians when facing different levels of BDQ resistance probability. Fourteen semi-structured interviews were conducted with physicians experienced in treating RR-TB, sampled purposefully from eight countries with varying income levels and burden of RR-TB. Five simulated patient scenarios were used as a trigger for discussion. Factors influencing the decision of physicians to prescr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-06-03T10:40:09.24Z","creation":"2025-04-19T20:36:43.404Z"},"accession":"S-EPMC9682818","cross_references":{"pubmed":["36418994"],"doi":["10.1186/s12879-022-07865-7"]}}