biostudies-literatureTu PHTFonds Wetenschappelijk Onderzoek876https://www.ebi.ac.uk/biostudies/studies/S-EPMC9682818biostudies-literatureUnknown22(1)<h4>Background</h4>Bedaquiline (BDQ) is a core drug for rifampicin-resistant tuberculosis (RR-TB) treatment. Accurate prediction of a BDQ-resistant phenotype from genomic data is not yet possible. A Bayesian method to predict BDQ resistance probability from next-generation sequencing data has been proposed as an alternative.<h4>Methods</h4>We performed a qualitative study to investigate the decision-making of physicians when facing different levels of BDQ resistance probability. Fourteen semi-structured interviews were conducted with physicians experienced in treating RR-TB, sampled purposefully from eight countries with varying income levels and burden of RR-TB. Five simulated patient scenarios were used as a trigger for discussion. Factors influencing the decision of physicians to prescrBMC infectious diseasesBedaquiline resistance probability to guide treatment decision making for rifampicin-resistant tuberculosis: insights from a qualitative study.PMC9682818G0F8316NLoos JDippenaar AConceicao ECTu PHTAnlay DZVan Rie AfalseBedaquiline resistance probability to guide treatment decision making for rifampicin-resistant tuberculosis: insights from a qualitative study.<h4>Background</h4>Bedaquiline (BDQ) is a core drug for rifampicin-resistant tuberculosis (RR-TB) treatment. Accurate prediction of a BDQ-resistant phenotype from genomic data is not yet possible. A Bayesian method to predict BDQ resistance probability from next-generation sequencing data has been proposed as an alternative.<h4>Methods</h4>We performed a qualitative study to investigate the decision-making of physicians when facing different levels of BDQ resistance probability. Fourteen semi-structured interviews were conducted with physicians experienced in treating RR-TB, sampled purposefully from eight countries with varying income levels and burden of RR-TB. Five simulated patient scenarios were used as a trigger for discussion. Factors influencing the decision of physicians to prescr2022-01-01T00:00:00Z2022 Nov2026-06-03T10:40:09.24Z2025-04-19T20:36:43.404ZS-EPMC96828183641899410.1186/s12879-022-07865-7