{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["17(11)"],"submitter":["Calvet L"],"funding":["Michelin Corporate Foundation"],"pubmed_abstract":["<h4>Objective</h4>COVID 19 is often associated with hypercoagulability and thromboembolic (TE) events. The aim of this study was to assess the characteristics of hypercoagulability and its relationship with new-onset TE events and the composite outcome of need for intubation and/or death in intensive care unit (ICU) patients admitted for COVID.<h4>Design</h4>Prospective observational study.<h4>Setting</h4>Monocentric, intensive care, University Hospital of Clermont Ferrand, France.<h4>Patients</h4>Patients admitted to intensive care from January 2020 to May 2021 for COVID-19 pneumonia.<h4>Interventions</h4>Standard hemostatic tests and rotational thromboelastometry (ROTEM) were performed on admission and on day 4. Hypercoagulability was defined by at least one of the following criteria: D-dimers > 3000 μg/dL, fibrinogen > 8 g/L, EXTEM CFT below the normal range, EXTEM A5, MCF, Li 60 above the normal range, and EXTEM G-score ((5000 x MCF) / (100-MCF)) ≥ 11 dyne/cm2.<h4>Measurements and main results</h4>Of the 133 patients included, 17 (12.7%) developed new-onset TE events, and 59 (44.3%) required intubation and/or died in the ICU. ROTEM was performed in 133 patients on day 1 and in 67 on day 4. Hypercoagulability was present on day 1 in 115 (86.4%) patients. None of the hypercoagulability indices were associated with subsequent new-onset TE events on days 1 and 4 nor with the need for intubation and/or ICU death. Hyperfibrinogenemia > 8g/dL, higher D-dimers and higher EXTEM Li 60 on day 4 were predictive of need for intubation and/or of ICU death.<h4>Conclusions</h4>Our study confirmed that most COVID-19 ICU patients have hypercoagulability on admission and almost all on day 4. Hyperfibrinogenemia or fibrinolysis shutdown on day 4 were associated with unfavorable outcome."],"journal":["PloS one"],"pagination":["e0277544"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9683576"],"repository":["biostudies-literature"],"pubmed_title":["Hypercoagulability in critically ill patients with COVID 19, an observational prospective study."],"pmcid":["PMC9683576"],"pubmed_authors":["Grapin K","Evrard B","Thouy F","Souweine B","Mascle O","Calvet L","Adda M","Sapin AF","Bonnet B","Dupuis C","Liteaudon JM"],"additional_accession":[]},"is_claimable":false,"name":"Hypercoagulability in critically ill patients with COVID 19, an observational prospective study.","description":"<h4>Objective</h4>COVID 19 is often associated with hypercoagulability and thromboembolic (TE) events. The aim of this study was to assess the characteristics of hypercoagulability and its relationship with new-onset TE events and the composite outcome of need for intubation and/or death in intensive care unit (ICU) patients admitted for COVID.<h4>Design</h4>Prospective observational study.<h4>Setting</h4>Monocentric, intensive care, University Hospital of Clermont Ferrand, France.<h4>Patients</h4>Patients admitted to intensive care from January 2020 to May 2021 for COVID-19 pneumonia.<h4>Interventions</h4>Standard hemostatic tests and rotational thromboelastometry (ROTEM) were performed on admission and on day 4. Hypercoagulability was defined by at least one of the following criteria: D-dimers > 3000 μg/dL, fibrinogen > 8 g/L, EXTEM CFT below the normal range, EXTEM A5, MCF, Li 60 above the normal range, and EXTEM G-score ((5000 x MCF) / (100-MCF)) ≥ 11 dyne/cm2.<h4>Measurements and main results</h4>Of the 133 patients included, 17 (12.7%) developed new-onset TE events, and 59 (44.3%) required intubation and/or died in the ICU. ROTEM was performed in 133 patients on day 1 and in 67 on day 4. Hypercoagulability was present on day 1 in 115 (86.4%) patients. None of the hypercoagulability indices were associated with subsequent new-onset TE events on days 1 and 4 nor with the need for intubation and/or ICU death. Hyperfibrinogenemia > 8g/dL, higher D-dimers and higher EXTEM Li 60 on day 4 were predictive of need for intubation and/or of ICU death.<h4>Conclusions</h4>Our study confirmed that most COVID-19 ICU patients have hypercoagulability on admission and almost all on day 4. Hyperfibrinogenemia or fibrinolysis shutdown on day 4 were associated with unfavorable outcome.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T13:27:47.027Z","creation":"2025-02-19T00:47:32.473Z"},"accession":"S-EPMC9683576","cross_references":{"pubmed":["36417476"],"doi":["10.1371/journal.pone.0277544"]}}